Sleep disturbances in children with ADHD on methylphenidate monotherapy: The role of dysregulation profile

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-02-06 DOI:10.1016/j.sleep.2025.02.001

Barbara D'Aiello , Ludovica Gessi , Deny Menghini , Stefano Vicari , Pietro De Rossi

{"title":"Sleep disturbances in children with ADHD on methylphenidate monotherapy: The role of dysregulation profile","authors":"Barbara D'Aiello , Ludovica Gessi , Deny Menghini , Stefano Vicari , Pietro De Rossi","doi":"10.1016/j.sleep.2025.02.001","DOIUrl":null,"url":null,"abstract":"<div><div>Dysregulation profile has been associated with Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents, influencing its progression, outcomes, and potentially the response to treatment with methylphenidate, a commonly prescribed stimulant medication. Sleep disturbances are also closely linked to ADHD, as they significantly impact clinical outcomes and overall functioning, with variable responses to methylphenidate treatment.</div><div>This study aimed to investigate whether methylphenidate improves sleep disturbances in children with ADHD and whether the presence of dysregulation profile negatively predicts this improvement. To explore this, we examined the role of baseline dysregulation profile (assessed with the Child Behavior Checklist), age, ADHD symptom severity (assessed with SNAP-IV scores), and functional impairment (assessed with ABAS-II scores) as potential predictors of changes in sleep disturbances (assessed with SDSC scores) following six months of methylphenidate monotherapy.</div><div>A total of 115 participants (98 males) aged 6–17 years (mean age 10.32 ± 2.78 years) were included in the study. A hierarchical linear regression model was used to determine whether these baseline factors could predict changes in sleep disturbances, while accounting for initial sleep severity.</div><div>The results showed that the presence of dysregulation profile at baseline was associated with higher sleep disturbances after treatment. While ADHD severity at baseline was associated with sleep disturbances at follow-up, it did not demonstrate any significant predictive value for sleep outcomes over time.</div><div>In conclusion, dysregulation profile may act as a negative predictor of sleep outcomes following methylphenidate treatment. These findings highlight the importance of systematically assessing dysregulation profile before starting treatment. Future research with larger sample sizes and longer follow-up periods is needed to confirm these results and identify additional factors that contribute to sleep disturbances in children and adolescents with ADHD.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Pages 153-158"},"PeriodicalIF":3.8000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1389945725000462","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Dysregulation profile has been associated with Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents, influencing its progression, outcomes, and potentially the response to treatment with methylphenidate, a commonly prescribed stimulant medication. Sleep disturbances are also closely linked to ADHD, as they significantly impact clinical outcomes and overall functioning, with variable responses to methylphenidate treatment.

This study aimed to investigate whether methylphenidate improves sleep disturbances in children with ADHD and whether the presence of dysregulation profile negatively predicts this improvement. To explore this, we examined the role of baseline dysregulation profile (assessed with the Child Behavior Checklist), age, ADHD symptom severity (assessed with SNAP-IV scores), and functional impairment (assessed with ABAS-II scores) as potential predictors of changes in sleep disturbances (assessed with SDSC scores) following six months of methylphenidate monotherapy.

A total of 115 participants (98 males) aged 6–17 years (mean age 10.32 ± 2.78 years) were included in the study. A hierarchical linear regression model was used to determine whether these baseline factors could predict changes in sleep disturbances, while accounting for initial sleep severity.

The results showed that the presence of dysregulation profile at baseline was associated with higher sleep disturbances after treatment. While ADHD severity at baseline was associated with sleep disturbances at follow-up, it did not demonstrate any significant predictive value for sleep outcomes over time.

In conclusion, dysregulation profile may act as a negative predictor of sleep outcomes following methylphenidate treatment. These findings highlight the importance of systematically assessing dysregulation profile before starting treatment. Future research with larger sample sizes and longer follow-up periods is needed to confirm these results and identify additional factors that contribute to sleep disturbances in children and adolescents with ADHD.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.