{"title":"Investigation of Thermophysical Properties and Hydration Behavior of Caffeine in the Presence of 2-Hydroxyethylammonium Lactate Protic Ionic Liquids","authors":"Nastaran Hamidinasab, Masumeh Mokhtarpour, Fariba Ghaffari, Hemayat Shekaari* and Behrang Golmohammadi, ","doi":"10.1021/acs.jced.4c0037310.1021/acs.jced.4c00373","DOIUrl":null,"url":null,"abstract":"<p >Caffeine is a supplemental and pharmaceutical compound for the human body to increase performance by controlling lactate content in the blood. Protic ionic liquids (PILs) are green neoteric solvents with potential pharmaceutical applications due to their biocompatibility with the human body. This study explores the molecular interactions between caffeine- and lactate-based PILs (2-hydroxyethylammonium lactate, bis(2-hydroxyethyl) ammonium lactate, and tris(2-hydroxyethyl) ammonium lactate). Experimental density, speed of sound, and viscosity measurements of caffeine in the aqueous PIL solutions at 298.15 K were measured to study solute-solvent interactions. Apparent molar properties, derived from density and speed of sound, were calculated using the Mason equation to obtain standard partial molar volume, partial molar isentropic compressibility, and transfer properties in aqueous solutions of PILs. Additionally, viscosity <i>B</i>-coefficients from the Jones–Dole equation were determined, providing insights into intermolecular interactions and the hydration behavior of caffeine in these systems.</p>","PeriodicalId":42,"journal":{"name":"Journal of Chemical & Engineering Data","volume":"70 2","pages":"684–693 684–693"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical & Engineering Data","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jced.4c00373","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Caffeine is a supplemental and pharmaceutical compound for the human body to increase performance by controlling lactate content in the blood. Protic ionic liquids (PILs) are green neoteric solvents with potential pharmaceutical applications due to their biocompatibility with the human body. This study explores the molecular interactions between caffeine- and lactate-based PILs (2-hydroxyethylammonium lactate, bis(2-hydroxyethyl) ammonium lactate, and tris(2-hydroxyethyl) ammonium lactate). Experimental density, speed of sound, and viscosity measurements of caffeine in the aqueous PIL solutions at 298.15 K were measured to study solute-solvent interactions. Apparent molar properties, derived from density and speed of sound, were calculated using the Mason equation to obtain standard partial molar volume, partial molar isentropic compressibility, and transfer properties in aqueous solutions of PILs. Additionally, viscosity B-coefficients from the Jones–Dole equation were determined, providing insights into intermolecular interactions and the hydration behavior of caffeine in these systems.
期刊介绍：
The Journal of Chemical & Engineering Data is a monthly journal devoted to the publication of data obtained from both experiment and computation, which are viewed as complementary. It is the only American Chemical Society journal primarily concerned with articles containing data on the phase behavior and the physical, thermodynamic, and transport properties of well-defined materials, including complex mixtures of known compositions. While environmental and biological samples are of interest, their compositions must be known and reproducible. As a result, adsorption on natural product materials does not generally fit within the scope of Journal of Chemical & Engineering Data.
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