Yifan Zhang, Fumin Xue, Ke Li, Maoyuan Liu, Shuai Yu* and Xiangchuan Wang*,
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引用次数: 0
Abstract
The solid–liquid equilibrium behavior of 5-hydroxy-1-methylpyrazole (HM) in 12 pure solvents including alcohol solvents (i.e., methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, and sec-butanol) and ester solvents (i.e., methyl acetate, ethyl acetate, propyl acetate, butyl acetate, and amyl acetate) was measured by the gravimetric method within the temperature range of 278.15–318.15 K. The solubility of HM is positively correlated to temperature in the above solvents. HM was more soluble in alcohols than in esters. Thermodynamic models, i.e., the modified Apelblat model, the Yaws model, and the Wilson model, were used to fit the solubility data. The relative average deviation and root-mean-square deviation values of the three models were no larger than 4.35 × 10–2 and 17.85 × 10–4. The selected theoretical models were able to correlate the solubility data of HM in the selected solvents well. Molecular electrostatic potential energy surface was used to analyze the molecular interactions. KAT-LSER model and Hansen solubility parameters were used to investigate the solvent effect. Furthermore, the dissolution process thermodynamic properties of HM were calculated on the basis of the Wilson model. The dissolution process of HM is spontaneous, endothermic, and entropy increasing.
期刊介绍:
The Journal of Chemical & Engineering Data is a monthly journal devoted to the publication of data obtained from both experiment and computation, which are viewed as complementary. It is the only American Chemical Society journal primarily concerned with articles containing data on the phase behavior and the physical, thermodynamic, and transport properties of well-defined materials, including complex mixtures of known compositions. While environmental and biological samples are of interest, their compositions must be known and reproducible. As a result, adsorption on natural product materials does not generally fit within the scope of Journal of Chemical & Engineering Data.