[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].

Q3 Medicine

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI:10.17116/jnevro202512501198

E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova

{"title":"[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].","authors":"E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova","doi":"10.17116/jnevro202512501198","DOIUrl":null,"url":null,"abstract":"Objective: To study the associations of NOS1AP gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.Material and methods: One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three NOS1AP polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.Results: Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (rs=0.262; p=0.021; pBonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with AA and AG rs12029454 (rs=0.717; p=0.00025; pbonf=0.0015), GG and GT rs10494366 (rs=0.381; p=0.008; pbonf=0.048), TT and CT rs12143842 (rs=0.389; p=0.003; pbonf=0.018) genotypes. We did not find any significant correlations in the group of women.Conclusion: Genetic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The AA/AG rs12029454, GG/GT rs10494366 and TT/CT rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"98-104"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/jnevro202512501198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To study the associations of NOS1AP gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.

Material and methods: One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three NOS1AP polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.

Results: Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r_s=0.262; p=0.021; p_Bonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with AA and AG rs12029454 (r_s=0.717; p=0.00025; p_bonf=0.0015), GG and GT rs10494366 (r_s=0.381; p=0.008; p_bonf=0.048), TT and CT rs12143842 (r_s=0.389; p=0.003; p_bonf=0.018) genotypes. We did not find any significant correlations in the group of women.

Conclusion: Genetic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The AA/AG rs12029454, GG/GT rs10494366 and TT/CT rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.

查看原文本刊更多论文

[NOS1AP基因多态性与接受抗精神病药物治疗的精神分裂症患者QT间期持续时间的关系]。

目的：探讨NOS1AP基因多态性与接受抗精神病药物治疗的精神分裂症患者QT间期（QTc）的关系。材料和方法：对168名确诊为精神分裂症的患者（78名男性和90名女性）进行了检查。患者接受基本的抗精神病药物治疗。入院时，进行了标准的12导联心电图记录。QTc区间的计算采用Bazett公式。选择3个NOS1AP多态性（rs12029454、rs10494366和rs12143842）进行基因分型。结果：Spearman相关显示男性组CPZeq与QTc间期持续时间有显著相关(rs=0.262；p = 0.021;pBonf = 0.042)。在AA和AG患者中，CPZeq与QTc间期持续时间呈正相关(rs=0.717；p = 0.00025;pbonf=0.0015)， GG和GT rs10494366 (rs=0.381；p = 0.008;pbonf=0.048)， TT和CT rs12143842 (rs=0.389；p = 0.003;pbonf = 0.018)基因型。我们在女性组中没有发现任何显著的相关性。结论：NOS1AP基因rs12029454、rs10494366和rs12143842基因变异与精神分裂症患者抗精神病药物应答QTc间期持续时间有关。男性AA/AG rs12029454、GG/GT rs10494366和TT/CT rs12143842基因型与QTc间期延长和不良心血管疾病的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova 医学-精神病学

CiteScore

1.10

自引率

0.00%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.