Mechanics of Single Cytoskeletal Filaments.

IF 10.4 1区 生物学 Q1 BIOPHYSICS
Guillaume Romet-Lemonne, Cécile Leduc, Antoine Jégou, Hugo Wioland
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引用次数: 0

Abstract

The cytoskeleton comprises networks of different biopolymers, which serve various cellular functions. To accomplish these tasks, their mechanical properties are of particular importance. Understanding them requires detailed knowledge of the mechanical properties of the individual filaments that make up these networks, in particular, microtubules, actin filaments, and intermediate filaments. Far from being homogeneous beams, cytoskeletal filaments have complex mechanical properties, which are directly related to the specific structural arrangement of their subunits. They are also versatile, as the filaments' mechanics and biochemistry are tightly coupled, and their properties can vary with the cellular context. In this review, we summarize decades of research on cytoskeletal filament mechanics, highlighting their most salient features and discussing recent insights from this active field of research.

单细胞骨架细丝的力学。
细胞骨架由不同的生物聚合物网络组成,具有不同的细胞功能。为了完成这些任务,它们的机械性能尤为重要。理解它们需要详细了解构成这些网络的单个丝的机械特性,特别是微管、肌动蛋白丝和中间丝。细胞骨架细丝远不是均匀的梁,而是具有复杂的力学性能,这与其亚基的特定结构安排直接相关。它们也是多用途的,因为细丝的力学和生物化学是紧密耦合的,它们的性质可以随着细胞环境的变化而变化。在这篇综述中,我们总结了几十年来关于细胞骨架细丝力学的研究,突出了它们最显著的特征,并讨论了这一活跃研究领域的最新见解。
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来源期刊
Annual Review of Biophysics
Annual Review of Biophysics 生物-生物物理
CiteScore
21.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.
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