The effectiveness and safety of auricular acupoint-related therapy for nicotine dependence: A systematic review and meta-analysis.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI:10.18332/tid/200550

Qindong Mi, Xiaolong Zhao, Zhijun Zhang, Fei Bao

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引用次数: 0

Abstract

Introduction: This study aims to systematically evaluate the efficacy and safety of auricular acupuncture-related therapies (AARTs) in managing nicotine dependence (ND).

Methods: We searched eight databases from their inception through December 2024 and screened randomized controlled trials (RCTs) evaluating AART for ND. The primary outcome was the ND cessation rate. We assessed study quality using the ROB-2 tool and applied the GRADE approach to determine the certainty or quality of of evidence.

Results: Nine RCTs involving 1032 patients were analyzed. Meta-analysis results indicate that AART significantly reduces the Minnesota Nicotine Withdrawal Scale score (MNWS) in ND patients compared to nicotine replacement therapy (NRT) (mean difference, MD=1.47; 95% CI: 0.06-2.88, p<0.05). However, no significant differences were observed in ND point cessation rate, Fagerström test for nicotine dependence score (FTND), Hamilton Anxiety Scale score (HAMA), daily smoking volume, or exhaled CO levels between AART and NRT. Notably, AART was associated with a lower incidence of adverse events compared to NRT (relative risk, RR=0.15; 95% CI: 0.04-0.56, p<0.01). There were also no significant differences in the ND point cessation rate between auricular-plaster therapy (APT), body acupuncture (BA), and the combination of APT and BA.

Conclusions: AART is effective in improving ND, showing greater efficacy in reducing MNWS and enhanced safety compared to NRT. Given the limited number of studies, the optimal AART regimen remains undetermined. Further research is needed to confirm and refine these findings.

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耳穴相关治疗尼古丁依赖的有效性和安全性：一项系统综述和荟萃分析。

前言：本研究旨在系统评价耳针相关疗法（AARTs）治疗尼古丁依赖（ND）的有效性和安全性。方法：我们检索了从建立到2024年12月的8个数据库，筛选了评估AART治疗ND的随机对照试验（rct）。主要终点是ND戒烟率。我们使用rob2工具评估研究质量，并采用GRADE方法确定证据的确定性或质量。结果：共分析了9项rct，共1032例患者。meta分析结果显示，与尼古丁替代疗法（NRT）相比，AART显著降低ND患者明尼苏达尼古丁戒断量表评分（MNWS）(平均差异，MD=1.47；结论：与NRT相比，AART可有效改善ND，降低MNWS的疗效更大，安全性更高。由于研究数量有限，最佳的抗逆转录病毒治疗方案仍未确定。需要进一步的研究来证实和完善这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.