Inflammatory Choroidal Neovascularization in Pediatric Uveitis: A Case Series.

IF 0.8 4区 医学 Q4 OPHTHALMOLOGY
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI:10.1055/a-2467-1804
Amandine Gauderon, Chiara Eandi, Aikaterini Koryllou, Florence Hoogewoud, Katerina Theodoropoulou, Yan Guex-Crosier
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引用次数: 0

Abstract

Background: The aim of our study is to describe clinical features, therapy, and outcome of children with inflammatory choroidal neovascularization (CNV).

Methods: Retrospective case series of children seen at the Jules-Gonin Eye Hospital between 2000 and 2024 with macular choroidal neovascularisation secondary to ocular inflammation.

Results: Four children (one male, three females) developed a retro-foveolar neovascular membrane after a median time of 2.5 months (range 1 - 16 months) following uveitis onset. The median age at presentation was 12 years (range 5 - 12 years). The CNV presentation was unilateral in all four cases, with three patients having posterior uveitis and one panuveitis. Two patients had idiopathic bilateral granulomatous uveitis while the other two had suspected toxoplasmosis chorioretinitis. Idiopathic cases were treated with oral steroids, with one patient being additionally treated with adalimumab. Toxoplasmosis cases were managed with antibiotics and oral steroids. CNV treatment involved a single anti-VEGF injection in two cases, six injections in one case, and no injection in one case due to CNV inactivity. Median follow-up period was 4.25 years (range 0.75 to 11 years) and the median final best-corrected visual acuity was 0.9 (range 0.6 - 1.25). No recurrence of CNV was observed, despite uveitis reactivation in two cases.

Conclusion: Anti-VEGF therapy is safe even in young children with minimal injections required to control the disease. Treating the underlying cause of uveitis with appropriate therapy is also crucial.

儿童葡萄膜炎的炎性脉络膜新生血管:一个病例系列。
背景:我们研究的目的是描述儿童炎症性脉络膜新生血管(CNV)的临床特征、治疗和结局。方法:回顾性分析2000 - 2024年在Jules-Gonin眼科医院就诊的继发于眼部炎症的黄斑脉络膜新生血管患儿的病例系列。结果:4名儿童(1名男性,3名女性)在葡萄膜炎发病2.5个月后(范围1 - 16个月)出现了小凹后新生血管膜。发病时的中位年龄为12岁(范围5 - 12岁)。所有4例CNV均为单侧表现,其中3例为后葡萄膜炎,1例为全葡萄膜炎。2例为特发性双侧肉芽肿性葡萄膜炎,2例疑似弓形虫病性脉络膜视网膜炎。特发性病例用口服类固醇治疗,1例患者另外用阿达木单抗治疗。弓形虫病病例用抗生素和口服类固醇治疗。CNV治疗包括2例单次注射抗vegf, 1例6次注射,1例因CNV无活性而不注射。中位随访期为4.25年(范围0.75 ~ 11年),中位最终最佳矫正视力为0.9(范围0.6 ~ 1.25)。尽管有2例葡萄膜炎复发,但未观察到CNV复发。结论:抗vegf治疗是安全的,即使在年幼的儿童中,只需少量注射即可控制疾病。用适当的治疗方法治疗葡萄膜炎的根本原因也是至关重要的。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
235
审稿时长
4-8 weeks
期刊介绍: -Konzentriertes Fachwissen aus Klinik und Praxis: Die entscheidenden Ergebnisse der internationalen Forschung - für Sie auf den Punkt gebracht und kritisch kommentiert, Übersichtsarbeiten zu den maßgeblichen Themen der täglichen Praxis, Top informiert - breite klinische Berichterstattung. -CME-Punkte sammeln mit dem Refresher: Effiziente, CME-zertifizierte Fortbildung, mit dem Refresher, 3 CME-Punkte pro Ausgabe - bis zu 36 CME-Punkte im Jahr!. -Aktuelle Rubriken mit echtem Nutzwert: Kurzreferate zu den wichtigsten Artikeln internationaler Zeitschriften, Schwerpunktthema in jedem Heft: Ausführliche Übersichtsarbeiten zu den wichtigsten Themen der Ophthalmologie – so behalten Sie das gesamte Fach im Blick!, Originalien mit den neuesten Entwicklungen, Übersichten zu den relevanten Themen.
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