Impact of wine polyphenols on the inflammatory profile of induced apical periodontitis in rats.

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-02-08 DOI:10.1016/j.joen.2025.01.023

Rafaela Ricci, Bharbara de Moura Pereira, Julissa Denisse Arguello Alvarado, Romulo de Oliveira Sales-Junior, Nathália Evelyn da Silva Machado, Doany Cevada Dos Santos, Felipe Haddad Martim Pederro, Marciane Magnani, Marcos Dos Santos Lima, Edilson Ervolino, Luciano Tavares Ângelo Cintra, Anil Kishen, João Eduardo Gomes-Filho

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引用次数: 0

Abstract

Introduction: This study evaluated the impact of dealcoholized red wine polyphenols on the inflammation and lesion volume associated with apical periodontitis (AP) in rats.

Methods: Thirty-two Wistar rats receiving AP induction were arranged as: Control Group (C), Dealcoholized Red Wine Group (DRW), Red Wine Group (W), and Alcohol Group (ALC). Solutions were administered daily in a volume of 4.28 mL/kg via gavage for 45 days. Mandibles and maxillae were removed for histological, immunohistochemical (IL-1β, IL-10, TNF-α, RANKL, OPG, TRAP) and micro-computed tomography analyses of the AP site. A statistical analysis was performed with a significance level of 5%.

Results: Inflammation and TRAP-positive cell count were similar for DRW and W, but lower when compared to C and ALC (p<0.001). The immunohistochemical expression of OPG was higher for DRW than for ALC (p<0.05). A larger lesion volume was observed in ALC compared to other groups (p<0.001).

Conclusions: Prophylactic administration of dealcoholized red wine significantly reduced inflammation, decreased the number of TRAP-positive cells, enhanced OPG expression, and reduced lesion volume compared to water and alcohol solutions.

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.