Intermediate filaments and their associated molecules.

IF 2.2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Jing Gao, Fumihiko Nakamura
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引用次数: 0

Abstract

Intermediate filaments (IFs) in human cells are the products of six distinct gene families, all sharing homology in a core rod domain. These IFs assemble into non-polar polymers, providing cytoplasmic and nuclear mechanical support. Recent research has revealed the active and dynamic properties of IFs and their binding partners. This regulation extends beyond cell mechanics to include migration, mechanotransduction, and tumor growth. This comprehensive review will catalog all human IF genes and IF-associated proteins (IFAPs), detailing their names, sizes, functions, associated human diseases, relevant literature, and links to resources like Uniprot and the Protein Atlas database. These links provide access to additional information such as protein structure, subcellular localization, disease-causing mutations, and pathology. Using this catalog, we will overview the current understanding of the biological functions of IFs and IFAPs. This overview is crucial for identifying gaps in their characterization and understanding IF-mediated mechanotransduction. Additionally, we will consider potential future research directions.

中间细丝及其相关分子。
人类细胞中的中间丝(if)是六个不同基因家族的产物,它们在一个核心棒状结构域共享同源性。这些if组装成非极性聚合物,提供细胞质和核的机械支持。最近的研究揭示了干扰素及其结合伙伴的活性和动态特性。这种调节超出了细胞力学,包括迁移、机械转导和肿瘤生长。这篇综合综述将对所有人类IF基因和IF相关蛋白(IFAPs)进行编目,详细说明它们的名称、大小、功能、相关的人类疾病、相关文献以及Uniprot和Protein Atlas数据库等资源的链接。这些链接提供了获取额外信息的途径,如蛋白质结构、亚细胞定位、致病突变和病理。利用这一目录,我们将概述目前对IFs和ifap生物学功能的了解。这一概述对于确定其表征和理解if介导的机械转导的差距至关重要。此外,我们将考虑潜在的未来研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biomedical Research
Journal of Biomedical Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.60
自引率
0.00%
发文量
69
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