Relationship between body mass index and traditional size-matching in heart transplantation.

IF 2.5 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ahad Firoz, Huaqing Zhao, Eman Hamad
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引用次数: 0

Abstract

Background: Donor-recipient size matching is an important consideration for heart allocation, of which predicted heart mass (PHM) ratio has been found to be the most optimal metric. However, the PHM formula has not been validated in a cohort that included obese recipients. Therefore, our study seeks to add further granular data on this topic by investigating acute survival in PHM categories across multiple body mass index (BMI) groups.

Methods: Adult heart transplant recipients were analyzed using the United Network for Organ Sharing database. BMI groups included: normal (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), obese class I (30.0-34.9 kg/m2), and obese class II+ (≥35.0 kg/m2). PHM ratio (PHMR) categories were: severely undersized (U2): <0.85, undersized (U1): 0.85-0.95, approximately equally sized (R): 0.95-1.05, oversized (O1): 1.05-1.25, and severely oversized (O2): ≥1.25. All-cause acute mortality was the primary outcome of interest.

Results: A total of 46,141 recipients were included in our analysis. The percentage of obese patients and donors increased over the years, from 21.5 % and 17.2 % in 2000 to 34.4 % and 33.1 % in 2022, respectively. Survival analysis found a stepwise reduction in mortality risk for severely undersized grafts as BMI increased (normal: HR = 1.59, p < 0.001; overweight: HR = 1.20, p = 0.029), until ultimately reaching insignificant levels in obese groups across all PHMR categories.

Conclusion: Patients with a normal to overweight BMI were susceptible to increased mortality with a severely undersized graft. Conversely, obese groups appeared to be resistant to the hazards of organ size mismatching by PHMR. The clinical implications of this study may enable recruitment from a larger donor pool and improve challenges in transplantation for obese patients.

心脏移植中体重指数与传统尺寸匹配的关系。
背景:供受体大小匹配是心脏分配的重要考虑因素,其中预测心脏质量比(PHMR)被认为是最理想的指标。然而,PHM公式尚未在包括肥胖接受者在内的队列中得到验证。因此,我们的研究试图通过调查多个体重指数(BMI)组中PHM类别的急性生存率来进一步增加这一主题的颗粒数据。方法:使用美国器官共享网络数据库对成人心脏移植受者进行分析。BMI组包括:正常(18.5 ~ 24.9 kg/m2)、超重(25.0 ~ 29.9 kg/m2)、肥胖I级(30.0 ~ 34.9 kg/m2)、肥胖II+级(≥35.0 kg/m2)。PHMR分类为:严重不足(U2):结果:我们的分析共纳入了46,141名接受者。肥胖患者和供体的比例逐年增加,分别从2000年的21.5% %和17.2% %增加到2022年的34.4% %和33.1% %。生存分析发现,随着BMI的增加,严重过小移植物的死亡风险逐步降低(正常:HR = 1.59,p )。结论:BMI正常至超重的患者易受严重过小移植物死亡率增加的影响。相反,肥胖组似乎对PHMR器官大小不匹配的危害有抵抗力。该研究的临床意义可能有助于从更大的供体池中招募,并改善肥胖患者的移植挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of cardiology
Journal of cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
4.90
自引率
8.00%
发文量
202
审稿时长
29 days
期刊介绍: The official journal of the Japanese College of Cardiology is an international, English language, peer-reviewed journal publishing the latest findings in cardiovascular medicine. Journal of Cardiology (JC) aims to publish the highest-quality material covering original basic and clinical research on all aspects of cardiovascular disease. Topics covered include ischemic heart disease, cardiomyopathy, valvular heart disease, vascular disease, hypertension, arrhythmia, congenital heart disease, pharmacological and non-pharmacological treatment, new diagnostic techniques, and cardiovascular imaging. JC also publishes a selection of review articles, clinical trials, short communications, and important messages and letters to the editor.
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