Effects of Moderate-Intensity Cyclic Normobaric Hypoxic Training on Cardiovascular Disease Risk Factors of Patients Recovered from COVID-19: The AEROBICOVID Randomized Controlled Trial.
Javier Brazo-Sayavera, Alba Camacho-Cardenosa, Talita Morais Fernandes, Jamille Guedes Malta Argolo, Ana Paula Morais Fernandes, Carlos Arterio Sorgi, Elisângela Aparecida da Silva Lizzi, Átila Alexandre Trapé
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引用次数: 0
Abstract
Brazo-Sayavera, Javier, Alba Camacho-Cardenosa, Talita Morais Fernandes, Jamille Guedes Malta Argolo, Ana Paula Morais Fernandes, Carlos Arterio Sorgi, Elisângela Aparecida da Silva Lizzi, and Átila Alexandre Trapé. Effects of moderate-intensity cyclic normobaric hypoxic training on cardiovascular disease risk factors of patients recovered from COVID-19: The AEROBICOVID randomized controlled trial. High Alt Med Biol. 00:00-00, 2025. Objectives: The aim was to analyze the effects of a training program under hypoxic conditions compared with a control and normoxia training program on cardiovascular disease risk factors in patients recovered from COVID-19. Methods: A total of 67 patients were randomly assigned to the control group, training and recovery with hypoxia (TH:RH), training in normoxia (TN) and recovery with hypoxia (RH), and TN and recovery in normoxia (RN). Anthropometric, body composition, respiratory, and cardiometabolic risk factors were analyzed before and after intervention. Results: All intervention groups had positive effects on various health outcomes in patients recovered from COVID-19. The reduction in waist, hip, and waist/hip ratio, glycaemia, total cholesterol, and low-density lipoprotein-cholesterol indicates improvements in cardiovascular health. The increase in the forced expiratory volume in 1 second suggests improvements in respiratory health. In addition, the decrease in cardiovascular disease risk score indicates a reduction in overall cardiovascular disease risk. Conclusions: The study provides evidence to support the clinical benefits of moderate-intensity intermittent hypoxic training as a part of the treatment of patients recovered from COVID-19. It may also provide evidence on the efficacy and safety of intermittent hypoxic training in different health conditions. The study was registered at the Brazilian Clinical Trials Registry (RBR-5d7hkv).
Brazo-Sayavera, Javier, Alba camaco - cardenosa, Talita Morais Fernandes, Jamille Guedes Malta Argolo, Ana Paula Morais Fernandes, Carlos Arterio Sorgi， elisngela aprecida da Silva Lizzi和Átila Alexandre trap。中等强度循环常压低氧训练对COVID-19康复患者心血管疾病危险因素的影响：有氧随机对照试验高Alt医学生物杂志，200,2025。目的：分析低氧条件下的训练计划与对照组和常氧训练计划对COVID-19康复患者心血管疾病危险因素的影响。方法：将67例患者随机分为对照组、低氧训练与恢复组（TH:RH）、低氧训练与恢复组（TN）、低氧训练与恢复组（RH）、低氧训练与恢复组（RN）。分析干预前后的人体测量、体成分、呼吸和心脏代谢危险因素。结果：各干预组对新冠肺炎康复患者各项健康结局均有积极影响。腰围、臀围、腰臀比、血糖、总胆固醇和低密度脂蛋白-胆固醇的减少表明心血管健康得到改善。1秒用力呼气量增加提示呼吸健康状况改善。此外，心血管疾病风险评分的降低表明总体心血管疾病风险的降低。结论：本研究为中强度间歇低氧训练作为COVID-19康复患者治疗的一部分的临床益处提供了证据。它也可能为间歇性低氧训练在不同健康状况下的有效性和安全性提供证据。该研究已在巴西临床试验登记处注册（RBR-5d7hkv）。
期刊介绍：
High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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