{"title":"Investigating Raman peak enhancement in carboxyl-rich molecules: insights from Au@Ag core-shell nanoparticles in colloids.","authors":"Junhao Chen, Zhengjia Chen, Tong Liang, Zhennan Zhang, Dahang Cheng, Shurui Liu, Haiyang Liu, Cuicui Liu, Xiaohui Song","doi":"10.3389/fchem.2025.1522043","DOIUrl":null,"url":null,"abstract":"<p><p>Surface-enhanced Raman scattering (SERS) is a promising analytical technique with applications in environmental monitoring, healthcare, and the biopharmaceutical industry. While SERS has been successfully applied to molecules such as 4-mercaptobenzoic acid and other thiol- and amine-containing compounds, there is limited research on its detection capabilities for molecules rich in carboxyl groups or unsaturated bonds, such as citric acid. This study investigates the SERS enhancement of Au@Ag core-shell nanoparticles in response to citric acid and other molecules with carboxyl and unsaturated bonds. We compare the SERS behavior of nanoparticles in freshly prepared and aged sodium citrate solutions to identify differences in Raman peak enhancement. Our findings show that the Au@Ag core-shell nanoparticles exhibit significant SERS enhancement when exposed to citric acid and other related compounds. The enhancement varies based on the age of the sodium citrate solution, which influences the structural properties of the nanoparticles. This work opens avenues for further research and applications in biological monitoring, environmental testing, and the pharmaceutical industry.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1522043"},"PeriodicalIF":3.8000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808131/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3389/fchem.2025.1522043","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Surface-enhanced Raman scattering (SERS) is a promising analytical technique with applications in environmental monitoring, healthcare, and the biopharmaceutical industry. While SERS has been successfully applied to molecules such as 4-mercaptobenzoic acid and other thiol- and amine-containing compounds, there is limited research on its detection capabilities for molecules rich in carboxyl groups or unsaturated bonds, such as citric acid. This study investigates the SERS enhancement of Au@Ag core-shell nanoparticles in response to citric acid and other molecules with carboxyl and unsaturated bonds. We compare the SERS behavior of nanoparticles in freshly prepared and aged sodium citrate solutions to identify differences in Raman peak enhancement. Our findings show that the Au@Ag core-shell nanoparticles exhibit significant SERS enhancement when exposed to citric acid and other related compounds. The enhancement varies based on the age of the sodium citrate solution, which influences the structural properties of the nanoparticles. This work opens avenues for further research and applications in biological monitoring, environmental testing, and the pharmaceutical industry.
期刊介绍:
Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide.
Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”.
All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.