Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles.

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-02-11 DOI:10.1080/09513590.2025.2463533
Ran Cheng, Ying Zhu, Liu-Qing Yang, Lu Xiao, Xiao-Hong Fang, Qin Zhang
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引用次数: 0

Abstract

Introduction: The clinical study aimed to evaluate the levels of serum kisspeptin, NKB, and GABA in Chinese patients with polycystic ovary syndrome (PCOS) and explore their association with hormonal profiles, as well as the relationship between these levels in PCOS patients and controls.

Methods: From December 2022 to December 2023, medical records of 60 individuals diagnosed with PCOS and 32 healthy subjects were obtained. Serum kisspeptin, NKB and GABA levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. To assess the correlation, either Pearson's or Spearman's analytical method was employed between serum kisspeptin, NKB, and GABA levels and hormonal profiles.

Results: The results showed that serum kisspeptin and NKB levels were significantly lower in PCOS patients (p﹤.05), while GABA levels were elevated compared to those in the control group (p﹤.05). In PCOS patients, kisspeptin was notably positive-correlated with LH and LH/FSH (p﹤.05), but no significant correlation was found between NKB, GABA, and hormonal profiles. In PCOS, GABA levels had a strong positive correlation with NKB levels (r = 0.613, p = .000), but this was not observed in the control group. In control patients, kisspeptin levels were positively associated with NKB (r = 0.475, p = .011), strongly negatively correlated with GABA levels (r = -0.773, p = .000), but these were not observed in the PCOS group.

Conclusion: The study concluded that patients with PCOS have dysregulated levels of serum kisspeptin, NKB, and GABA and that they may have paradoxical effects under physiological and pathological situations.

多囊卵巢综合征妇女血清kisspeptin、NKB、GABA水平异常及其与激素谱的关系
摘要:本临床研究旨在评估中国多囊卵巢综合征(PCOS)患者血清kisspeptin、NKB和GABA水平,探讨其与激素谱的关系,以及PCOS患者和对照组血清kisspeptin、NKB和GABA水平的关系。方法:获取2022年12月至2023年12月60例PCOS患者和32例健康受试者的病历。采用酶联免疫吸附测定(ELISA)试剂盒定量测定血清kisspeptin、NKB和GABA水平。为了评估相关性,采用Pearson或Spearman分析方法分析血清kisspeptin、NKB和GABA水平与激素谱之间的关系。结果:PCOS患者血清kisspeptin、NKB水平明显低于对照组(p< 0.05), GABA水平明显高于对照组(p< 0.05)。在PCOS患者中,kisspeptin与LH和LH/FSH呈显著正相关(p< 0.05),而NKB、GABA与激素谱无显著相关。在多囊卵巢综合征中,GABA水平与NKB水平有很强的正相关(r = 0.613, p = .000),但在对照组中没有观察到这种情况。在对照患者中,kisspeptin水平与NKB呈正相关(r = 0.475, p = 0.011),与GABA水平呈强负相关(r = -0.773, p = 0.000),但在PCOS组中未观察到这些。结论:本研究认为PCOS患者血清kisspeptin、NKB和GABA水平失调,在生理和病理情况下可能具有矛盾的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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