Sleep duration, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A prospective cohort study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-02-08 DOI:10.1016/j.diabres.2025.112026

Xiaoge Niu , Hongwei Liu , Yanxi Wang , Yanfang Lu , Xiaojing Jiao , Yafeng Ren , Lei Yan , Shaokai Zhang , Huixia Cao , Fengmin Shao

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Abstract

Background

Associations between sleep duration and incident diabetic microvascular complications remain uncertain. The potential biological pathways underlying the association are unclear.

Methods

This prospective cohort study included 24,081 participants with type 2 diabetes from the UK Biobank. Habitual sleep duration was obtained via a baseline questionnaire. Associations of sleep duration with microvascular complications were analyzed using Cox regression models.

Results

The association of sleep duration with composite microvascular complications followed U-shaped patterns. Compared with sleeping for 7 hrs/day, the hazard ratios (95 % confidence intervals) of ≤ 5 and ≥ 10 hrs/day were 1.21 (1.09, 1.35) and 1.24 (1.09, 1.42) for the composite outcome, 1.20 (1.04, 1.38) and 1.30 (1.09, 1.54) for diabetic kidney disease, 1.61 (1.30, 2.00) and 1.35 (1.01, 1.79) for diabetic neuropathy, and 1.10 (0.93, 1.30) and 1.17 (0.95, 1.44) for diabetic retinopathy. Body mass index, gamma-glutamyl transferase, C-reactive protein, alkaline phosphatase, total cholesterol, and low-density lipoprotein cholesterol collectively explained 20.34 % of the association between sleep duration and composite microvascular complications.

Conclusions

Our study demonstrated that both short and long sleep durations were independently associated with increased risk of diabetic microvascular complications. The associations were partially mediated by metabolic biomarkers related to obesity, systemic inflammation, liver function, and lipid profile.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.