Laboratory Monitoring in Transgender and Gender-Diverse Individuals.

IF 7.1 2区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Clinical chemistry Pub Date : 2025-03-03 DOI:10.1093/clinchem/hvaf001

Brendan J Nolan, Ada S Cheung

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引用次数: 0

Abstract

Background: Increasing numbers of transgender and gender-diverse individuals are seeking initiation of gender-affirming hormone therapy. This aligns an individual's physical characteristics with their gender identity and improves psychological outcomes. Physical changes, including changes to muscle mass and body fat redistribution, can alter sex-specific laboratory reference ranges.

Content: We review the impact of gender-affirming hormone therapy on laboratory parameters with sex-specific reference ranges, with a focus on hemoglobin/hematocrit, renal function, cardiac biomarkers, and prostate-specific antigen.

Summary: Gender-affirming hormone therapy results in changes in laboratory parameters with sex-specific reference ranges. For individuals established on gender-affirming hormone therapy, reference ranges that align with an individual's gender identity should be used for hemoglobin/hematocrit, serum creatinine, and high-sensitivity cardiac troponin and N-terminal brain natriuretic peptide. Clinicians should interpret these biomarkers according to the reference range that aligns with one's affirmed gender.

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跨性别和性别多样化个体的实验室监测。

背景：越来越多的跨性别者和性别多样化的个体正在寻求启动性别确认激素治疗。这使一个人的身体特征与他们的性别认同保持一致，并改善心理结果。身体变化，包括肌肉量和身体脂肪再分配的变化，可以改变性别特异性的实验室参考范围。内容：我们回顾了性别确认激素治疗对实验室参数的影响，这些参数具有性别特异性参考范围，重点是血红蛋白/红细胞压积、肾功能、心脏生物标志物和前列腺特异性抗原。摘要：性别确认激素治疗导致实验室参数的变化与性别特定的参考范围。对于接受性别确认激素治疗的个体，血红蛋白/红细胞压积、血清肌酐、高敏感性心肌肌钙蛋白和n端脑钠肽的参考范围应与个体的性别认同一致。临床医生应该根据参考范围来解释这些生物标志物，这些参考范围与一个人确认的性别一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical chemistry 医学-医学实验技术

CiteScore

11.30

自引率

4.30%

发文量

212

审稿时长

1.7 months

期刊介绍： Clinical Chemistry is a peer-reviewed scientific journal that is the premier publication for the science and practice of clinical laboratory medicine. It was established in 1955 and is associated with the Association for Diagnostics & Laboratory Medicine (ADLM). The journal focuses on laboratory diagnosis and management of patients, and has expanded to include other clinical laboratory disciplines such as genomics, hematology, microbiology, and toxicology. It also publishes articles relevant to clinical specialties including cardiology, endocrinology, gastroenterology, genetics, immunology, infectious diseases, maternal-fetal medicine, neurology, nutrition, oncology, and pediatrics. In addition to original research, editorials, and reviews, Clinical Chemistry features recurring sections such as clinical case studies, perspectives, podcasts, and Q&A articles. It has the highest impact factor among journals of clinical chemistry, laboratory medicine, pathology, analytical chemistry, transfusion medicine, and clinical microbiology. The journal is indexed in databases such as MEDLINE and Web of Science.