The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases.

IF 5.9 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-02-11 DOI:10.1111/cpr.13804

Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He

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Abstract

In spite of great advances in modern medicine, there are a few effective strategies for the treatment of neurodegenerative diseases characterised by neuron loss or degeneration. This results from complex pathogenesis of the diseases and the limited drug uptake of the brain due to the presence of blood-brain barrier. Nanoparticle-based drug delivery systems are expected to improve the drug utilisation. Polymeric nanoparticles represent promising drug delivery carriers to the brain due to their unique advantages such as good biodegradability and biocompatibility, flexibility in surface modification and nontoxicity. In addition, the delivery of genetic drugs may stop the progression of neurodegenerative diseases at the genetic level and even avoid the irreversible damage in the central nervous system. In this review, an overview of studies on polymer-based nanoparticles for drug delivery to the central nervous system in typical neurodegenerative diseases, especially Alzheimer's diseases and Parkinson's diseases, is described. Meanwhile, their applications in gene delivery in these disorders are discussed. And the challenges and future perspectives for the development of polymeric nanoparticles as drug delivery carriers in neurodegenerative diseases are concluded.

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高分子纳米颗粒作为神经退行性疾病细胞药物递送载体的应用。

尽管现代医学取得了巨大的进步，但对于以神经元丧失或变性为特征的神经退行性疾病的治疗，仍有一些有效的策略。这是由于疾病的复杂发病机制和由于血脑屏障的存在而限制了大脑对药物的摄取。纳米颗粒给药系统有望提高药物的利用率。聚合物纳米颗粒具有良好的生物可降解性和生物相容性、表面修饰的灵活性和无毒性等独特优势，是一种很有前途的脑药物递送载体。此外，基因药物的递送可能在遗传水平上阻止神经退行性疾病的进展，甚至避免中枢神经系统的不可逆损伤。本文综述了聚合物基纳米颗粒在典型神经退行性疾病，特别是阿尔茨海默病和帕金森病中用于中枢神经系统药物递送的研究概况。同时讨论了它们在这些疾病基因传递中的应用。总结了高分子纳米颗粒作为神经退行性疾病药物传递载体的发展面临的挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.