Association between periodontitis and carotid atherosclerosis: an updated systematic review and meta-analysis.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-02-10 DOI:10.1159/000543955

Fangfei Ye, Min Chen, Qun Zhou

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引用次数: 0

Abstract

Introduction Current studies on the relationship between periodontitis and carotid atherosclerosis (CAS) remain inconclusive. This updated meta-analysis was conducted to evaluate the relevant observational studies to drive a definite conclusion. Methods Four major databases were searched for observational studies regarding the relationship between periodontitis and CAS published up to 14 December 2023. Software STATA 14.0 was used to calculate pooled odds ratios (OR) and 95% confidence interval (CI) in random effects model. Results Twenty-six articles were finally included. Periodontitis was significantly associated with CAS (OR = 1.97, 95% CI = 1.64 - 2.36; p = 0.000)，however, statistical heterogeneity among studies. Sensitivity analysis indicated our results were robust. Although publication bias was observed, odds ratio corrected by the trim-and-fill method was still increased (OR = 1.30, 95% CI = 1.06 - 1.58; p = 0.000). Conclusion The findings revealed a significant association between periodontitis and CAS. However, long-term randomized controlled trials should be conducted to identify the causality.

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引言目前关于牙周炎与颈动脉粥样硬化（CAS）之间关系的研究仍无定论。本项最新荟萃分析旨在评估相关的观察性研究，以得出明确的结论。方法检索四个主要数据库中截至 2023 年 12 月 14 日发表的有关牙周炎与 CAS 关系的观察性研究。使用 STATA 14.0 软件在随机效应模型中计算汇总的几率比（OR）和 95% 的置信区间（CI）。结果最终纳入了 26 篇文章。牙周炎与 CAS 明显相关（OR = 1.97，95% CI = 1.64 - 2.36；P = 0.000），但不同研究之间存在统计学异质性。敏感性分析表明我们的结果是可靠的。虽然观察到了发表偏倚，但经修剪填充法校正的几率比仍有所增加（OR = 1.30，95% CI = 1.06 - 1.58；P = 0.000）。结论研究结果表明，牙周炎与 CAS 之间存在显著关联。然而，应进行长期随机对照试验以确定其因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.