Palladium-catalyzed domino cyclization and C–H amination of 1,7-enynes toward N-containing fused quinolin-2(1H)-ones†

Abstract

A palladium-catalyzed domino radical cyclization and C–H amination of 1,7-enynes has been developed for the rapid establishment of N-containing fused quinolin-2(1H)-one scaffolds. The reaction of 1,7-enynes with perfluoroalkyl iodides and di-t-butyldiaziridinone worked well to give a wide range of N-containing fused quinolin-2(1H)-one derivatives in high yields. Notably, this method could be used in the late-stage modifications of various drugs.