Longitudinal Identification of Pre-Lesional Tissue in Multiple Sclerosis With Advanced Diffusion MRI

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-02-12 DOI:10.1111/jon.70022

Maria Caranova, Júlia F. Soares, Daniela Jardim Pereira, Ana Cláudia Lima, Lívia Sousa, Sónia Batista, Miguel Castelo-Branco, João V. Duarte

{"title":"Longitudinal Identification of Pre-Lesional Tissue in Multiple Sclerosis With Advanced Diffusion MRI","authors":"Maria Caranova, Júlia F. Soares, Daniela Jardim Pereira, Ana Cláudia Lima, Lívia Sousa, Sónia Batista, Miguel Castelo-Branco, João V. Duarte","doi":"10.1111/jon.70022","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Purpose</h3>\n \n <p>Structural MRI (sMRI) is used in monitoring multiple sclerosis (MS) but lacks sensitivity in detecting clinically relevant damage to normal-appearing white matter (NAWM), that is, pre-lesional tissue, and specificity for identifying the underlying substrate of injury. In this longitudinal study, we identified pre-lesional tissue in MS patients and investigated its microstructure by modeling diffusion-weighted imaging (DWI) data using diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We enrolled 18 patients with relapsing-remitting MS (10 females, 31.92 ± 8.09 years, disease duration 0.91 ± 1.81 years) and 18 healthy controls (10 females, 31.89 ± 8.15 years). Participants underwent two sMRI and DWI sessions (baseline and follow-up) with the same protocols. Average apparent diffusion coefficient (ADC), fractional anisotropy (FA), orientation dispersion index (ODI), and neurite density index (NDI) were estimated in data-driven regions of interest: nonpersistent lesional tissue (lesional tissue at baseline, resolved at follow-up), lesions that only existed at follow-up (pre-lesional tissue at baseline, lesions at follow-up), persistent lesional tissue (lesions at baseline and follow-up), and NAWM.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared to NAWM, pre-lesional tissue showed lower ODI, and resolved lesional tissue showed higher FA and ADC and lower ODI and NDI. Over time, persistent lesional tissue showed a decrease in FA and ODI and an increase in NDI. Compared to nonpersistent lesional tissue, persistent lesional tissue showed higher ADC and lower NDI.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>DWI and, more particularly, NODDI, can reveal the unique microstructure of persistent, resolved, and pre-lesional tissue in MS.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jon.70022","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Purpose

Structural MRI (sMRI) is used in monitoring multiple sclerosis (MS) but lacks sensitivity in detecting clinically relevant damage to normal-appearing white matter (NAWM), that is, pre-lesional tissue, and specificity for identifying the underlying substrate of injury. In this longitudinal study, we identified pre-lesional tissue in MS patients and investigated its microstructure by modeling diffusion-weighted imaging (DWI) data using diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI).

Methods

We enrolled 18 patients with relapsing-remitting MS (10 females, 31.92 ± 8.09 years, disease duration 0.91 ± 1.81 years) and 18 healthy controls (10 females, 31.89 ± 8.15 years). Participants underwent two sMRI and DWI sessions (baseline and follow-up) with the same protocols. Average apparent diffusion coefficient (ADC), fractional anisotropy (FA), orientation dispersion index (ODI), and neurite density index (NDI) were estimated in data-driven regions of interest: nonpersistent lesional tissue (lesional tissue at baseline, resolved at follow-up), lesions that only existed at follow-up (pre-lesional tissue at baseline, lesions at follow-up), persistent lesional tissue (lesions at baseline and follow-up), and NAWM.

Results

Compared to NAWM, pre-lesional tissue showed lower ODI, and resolved lesional tissue showed higher FA and ADC and lower ODI and NDI. Over time, persistent lesional tissue showed a decrease in FA and ODI and an increase in NDI. Compared to nonpersistent lesional tissue, persistent lesional tissue showed higher ADC and lower NDI.

Conclusions

DWI and, more particularly, NODDI, can reveal the unique microstructure of persistent, resolved, and pre-lesional tissue in MS.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!