Optimization and assessment of the metabolites from the Corrigiola telephiifolia Pourr. roots, using response surface methodology

IF 1.2 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science Pub Date : 2025-02-02 DOI:10.1016/j.kjs.2025.100383

Wissal El Yaagoubi , Smail Aazza , Meriem Soussi , Saadia Belmalha , Amal Alotaibi , Salah-Eddine Laasli , Rachid Lahlali , Lahsen El Ghadraoui

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引用次数: 0

Abstract

Corrigiola telephiifolia Pourr. is recognized for its health-promoting effects due to its rich bioactive compound content, particularly antioxidants. This study aimed to optimize the extraction of phenolic compounds from dried C. telephiifolia roots using various solvent combinations. A centroid simplex statistical approach was employed to evaluate the impact of different organic solvents—methanol, ethanol, and water—on extraction efficiency. The results indicated that a 50% methanol and 50% water binary combination yielded the highest total phenolic content, while an equal combination of methanol, ethanol, and water maximized total flavonoid content. Additionally, the hydromethanolic extract (50%, 50%) demonstrated the optimum antioxidant activity, with specific solvent mixtures enhancing DPPH scavenging activity and FRAP values. The optimized solvent proportions for total antioxidant capacity were 60.8% water, 30.3% ethanol, and 8.9% methanol. These findings suggest that the optimized extraction models are cost-effective and efficient, providing a valuable method for extracting high-quality phytocompounds.

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来源期刊

Kuwait Journal of Science MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

28.60%

发文量

132

期刊介绍： Kuwait Journal of Science (KJS) is indexed and abstracted by major publishing houses such as Chemical Abstract, Science Citation Index, Current contents, Mathematics Abstract, Micribiological Abstracts etc. KJS publishes peer-review articles in various fields of Science including Mathematics, Computer Science, Physics, Statistics, Biology, Chemistry and Earth & Environmental Sciences. In addition, it also aims to bring the results of scientific research carried out under a variety of intellectual traditions and organizations to the attention of specialized scholarly readership. As such, the publisher expects the submission of original manuscripts which contain analysis and solutions about important theoretical, empirical and normative issues.