The impact of MTHFR and VDR polymorphisms on endometriosis susceptibility: Insights from a systematic review and meta-analysis

IF 2.9 3区 医学 Q3 IMMUNOLOGY
Ruting Zhang , Hanxin Lv , Jinghua Liu , Jiashan Yin , Shuang Wu , Yuyang Xie , Huihui Xing , Rui Wang , Zefan Zhao , Bimin Shi , Xiaoqin Yang , Shangshang Gao
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引用次数: 0

Abstract

The VDR and MTHFR polymorphisms have been linked to many gynecological and obstetrical diseases. However, there is still a pressing need for a systematic review and meta-analysis to synthesize the current evidence on the association between these variants and endometriosis risk. English and Chinese literature databases were systematically retrieved to find relevant research published up to August 1, 2024. The meta-analytic calculations were implemented in the R language 4.4.1 environment. The odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were estimated to assess the magnitude of the effect. In total, 26 datasets comprising 9300 subjects were included. The pooled estimate demonstrated a significant association between the MTHFR C677T polymorphism and endometriosis susceptibility in the allele model (OR: 1.41, 95 % CI: 1.07–1.86, P = 0.01), homozygote model (OR: 2.09, 95 % CI: 1.56–2.79, P < 0.01), dominant model (OR: 1.48, 95 % CI: 1.06–2.07, P = 0.02), and recessive model (OR: 1.81, 95 % CI: 1.38–2.37, P < 0.01). However, the meta-analysis for the MTHFR A1298C polymorphism and the VDR FokI, TaqI, ApaI, and BsmI polymorphic variants did not find statistical significance. In conclusion, this meta-analysis suggests that the MTHFR C677T polymorphism might play a role in developing endometriosis disease. Meanwhile, further large-scale validations that consider multiple factors are warranted to confirm this finding.
MTHFR和VDR多态性对子宫内膜异位症易感性的影响:来自系统回顾和荟萃分析的见解
VDR和MTHFR多态性与许多妇科和产科疾病有关。然而,仍然迫切需要系统回顾和荟萃分析来综合这些变异与子宫内膜异位症风险之间关系的现有证据。系统检索中英文文献数据库,查找截止到2024年8月1日发表的相关研究。元分析计算在R语言4.4.1环境中实现。估计比值比(ORs)和相应的95 %置信区间(95 % ci)来评估影响的程度。共纳入26个数据集,9300名受试者。汇集估计显示出重要的协会之间的MTHFR C677T多态性和子宫内膜异位症易感性的等位基因模型(OR: 1.41, 95 % CI: 1.07 - -1.86, P = 0.01),纯合子模型(OR: 2.09, 95 % CI: 1.56 - -2.79, P & lt; 0.01),占主导地位的模式(OR: 1.48, 95 % CI: 1.06 - -2.07, P = 0.02),和隐性模型(OR: 1.81, 95 % CI: 1.38 - -2.37, P & lt; 0.01)。然而,对MTHFR A1298C多态性和VDR FokI、TaqI、ApaI和BsmI多态性变异的meta分析没有发现统计学意义。总之,本荟萃分析提示MTHFR C677T多态性可能在发生子宫内膜异位症中发挥作用。同时,进一步的大规模验证,考虑多个因素,有必要证实这一发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.30
自引率
5.90%
发文量
162
审稿时长
10.6 weeks
期刊介绍: Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology. This encompasses normal and pathological processes of: * Male and Female Reproductive Tracts * Gametogenesis and Embryogenesis * Implantation and Placental Development * Gestation and Parturition * Mammary Gland and Lactation.
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