Radiation-induced osteosarcoma in the head and neck region: Case report and literature review

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-02-12 DOI:10.1016/j.oraloncology.2025.107216

Iara Vieira Ferreira , Marcelo Elias Schempf Cattan , Carlos Takahiro Chone , Arthur Antolini , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano

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引用次数: 0

Abstract

Radiation-induced sarcoma (RIS) is a rare but highly aggressive complication of radiotherapy, especially in the head and neck region (RIS-HN). This report describes a case of radiation-induced osteosarcoma (RIOS) in a 32-year-old woman with a history of craniopharyngioma treated with surgery and radiotherapy 13 years prior. The patient exhibited symptoms including epistaxis, diplopia, and ptosis of the right eyelid. Imaging revealed a large, inoperable tumor in the area that had received prior radiotherapy. A biopsy confirmed the diagnosis of osteosarcoma, and the patient initiated palliative chemotherapy. Unfortunately, the treatment was unsuccessful, and the patient passed away. A review of 148 RIOS cases published in the last 25 years in the literature shows that the maxilla and mandible are the most affected sites (68.86 %), with an average latency of 11.79 years. The most common primary tumor was nasopharyngeal carcinoma, treated with an average radiation dose of 61.69 Gy. The prognosis remains poor, with 72.3 % of patients dying within an average of 23 months of follow-up. This study highlights the clinical and pathological characteristics of RIOS, the importance of long-term monitoring of irradiated patients to detect and treat these tumors early, with the aim of improving patient outcomes.

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.