Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases

Abstract

Background

Recent studies suggest neuromodulation as a potential therapeutic strategy for neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD), despite their complex pathophysiology and limited treatments' efficacy, requiring further investigation.

Objective

This study aims to explore the impact of neuromodulation techniques on the symptoms and progression of AD and PD, focusing on their underlying mechanisms and therapeutic benefits.

Method

A comprehensive review of recent literature was conducted, encompassing published articles, results of clinical trials, animal studies, and meta-analyses regarding various neuromodulation techniques, including transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and transcranial direct current stimulation (tDCS). Data on cognitive function, motor control, and quality of life were extracted and analyzed.

Results

Neuromodulation techniques demonstrated promising outcomes in both AD and PD. TMS showed significant improvement in cognitive functions in AD patients, while DBS resulted in substantial relief of motor symptoms and improved quality of life in PD patients. Additionally, mechanisms such as enhanced neuroplasticity, modulation of neurotransmitter systems, and the potential for neuroprotective effects were identified as key contributors to these benefits.

Conclusion

Neuromodulation offers potential therapeutic solutions for managing symptoms and slowing neurodegenerative disorders like AD and PD, but further research is needed to understand long-term effects and optimal protocols.