Six new compounds with neuroprotective activity from the leaves of Paeonia lactiflora Pall

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-10 DOI:10.1016/j.fitote.2025.106435

Xin-Yu Min , Jia-Tong Wu , Meng-Ting Wang, Peng Jiang, Si-Yi Wang, Anam Naseem, Yu-Qing Wang, Gui-Qin Ma, Juan Pan, Meng-Meng Li, Wei Guan, Hai-Xue Kuang, Bing-You Yang, Yan Liu

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引用次数: 0

Abstract

Twenty constituents, three new terpenes named Paeoniterpene A-C (1–3), and three new fatty glycosides named Paeoniglycoside A-C (4–6) were isolated from the leaves of Paeonia lactiflora Pall. The structures of compounds 1–6 were identified using extensive spectroscopic methods, such as NMR, MS, CD, IR, and UV. Compounds 4–6 were characterized through quantum chemical calculations and DP4⁺ probability analysis, and ECD definitively confirmed their structures. Additionally, all compounds were assessed for their neuroprotective effects against H₂O₂-induced damage in PC 12 cells. Compounds 1–3, 7, 8, 11, and 12 could significantly improve H₂O₂-induced PC 12 injury.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.