Exploiting Online Spatially Resolved Dynamic Light Scattering and Flow-NMR for Automated Size Targeting of PISA-Synthesized Block Copolymer Nanoparticles

IF 4.7 Q1 POLYMER SCIENCE
Peter M. Pittaway, Kudakwashe E. Chingono, Stephen T. Knox, Elaine Martin, Richard A. Bourne, Olivier J. Cayre, Nikil Kapur, Jonathan Booth, Robin Capomaccio, Nicholas Pedge and Nicholas J. Warren*, 
{"title":"Exploiting Online Spatially Resolved Dynamic Light Scattering and Flow-NMR for Automated Size Targeting of PISA-Synthesized Block Copolymer Nanoparticles","authors":"Peter M. Pittaway,&nbsp;Kudakwashe E. Chingono,&nbsp;Stephen T. Knox,&nbsp;Elaine Martin,&nbsp;Richard A. Bourne,&nbsp;Olivier J. Cayre,&nbsp;Nikil Kapur,&nbsp;Jonathan Booth,&nbsp;Robin Capomaccio,&nbsp;Nicholas Pedge and Nicholas J. Warren*,&nbsp;","doi":"10.1021/acspolymersau.4c0007410.1021/acspolymersau.4c00074","DOIUrl":null,"url":null,"abstract":"<p >Programmable synthesis of polymer nanoparticles prepared by polymerization-induced self-assembly (PISA) mediated by reversible addition–fragmentation chain-transfer (RAFT) dispersion polymerization with specified diameter is achieved in an automated flow-reactor platform. Real-time particle size and monomer conversion is obtained via inline spatially resolved dynamic light scattering (SRDLS) and benchtop nuclear magnetic resonance (NMR) instrumentation. An initial training experiment generated a relationship between copolymer block length and particle size for the synthesis of poly(<i>N</i>,<i>N</i>-dimethylacrylamide)-<i>b</i>-poly(diacetone acrylamide) (PDMAm-<i>b</i>-PDAAm) nanoparticles. The training data was used to target the product compositions required for synthesis of nanoparticles with defined diameters of 50, 60, 70, and 80 nm, while inline NMR spectroscopy enabled rapid acquisition of kinetic data to support their scale-up. NMR and SRDLS were used during the continuous manufacture of the targeted products to monitor product consistency while an automated sampling system collected practically useful quantities of the targeted products, thus outlining the potential of the platform as a tool for discovery, development, and manufacture of polymeric nanoparticles.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 1","pages":"1–9 1–9"},"PeriodicalIF":4.7000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acspolymersau.4c00074","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS polymers Au","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acspolymersau.4c00074","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Programmable synthesis of polymer nanoparticles prepared by polymerization-induced self-assembly (PISA) mediated by reversible addition–fragmentation chain-transfer (RAFT) dispersion polymerization with specified diameter is achieved in an automated flow-reactor platform. Real-time particle size and monomer conversion is obtained via inline spatially resolved dynamic light scattering (SRDLS) and benchtop nuclear magnetic resonance (NMR) instrumentation. An initial training experiment generated a relationship between copolymer block length and particle size for the synthesis of poly(N,N-dimethylacrylamide)-b-poly(diacetone acrylamide) (PDMAm-b-PDAAm) nanoparticles. The training data was used to target the product compositions required for synthesis of nanoparticles with defined diameters of 50, 60, 70, and 80 nm, while inline NMR spectroscopy enabled rapid acquisition of kinetic data to support their scale-up. NMR and SRDLS were used during the continuous manufacture of the targeted products to monitor product consistency while an automated sampling system collected practically useful quantities of the targeted products, thus outlining the potential of the platform as a tool for discovery, development, and manufacture of polymeric nanoparticles.

利用在线空间分辨动态光散射和流动核磁共振技术自动定位pisa合成的嵌段共聚物纳米颗粒的尺寸
在自动化流动反应器平台上,实现了由可逆加成-破碎链转移(RAFT)分散聚合介导的聚合诱导自组装(PISA)制备的具有特定直径的聚合物纳米颗粒的可编程合成。实时粒度和单体转化通过内联空间分辨动态光散射(SRDLS)和台式核磁共振(NMR)仪器获得。通过初步训练实验,得到了合成聚(N,N-二甲基丙烯酰胺)-b-聚(二丙酮丙烯酰胺)(PDMAm-b-PDAAm)纳米粒子的共聚物嵌段长度与粒径之间的关系。训练数据用于合成直径为50,60,70和80nm的纳米颗粒所需的产品成分,而在线核磁共振波谱可以快速获取动力学数据,以支持其扩大规模。在目标产品的连续制造过程中,使用NMR和SRDLS来监测产品的一致性,同时自动采样系统收集了目标产品的实际有用数量,从而概述了该平台作为发现、开发和制造聚合物纳米颗粒的工具的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.50
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信