Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study.

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

Journal of pharmacy & bioallied sciences Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI:10.4103/jpbs.jpbs_1104_24

Saloni Verma, Annuroopa Mahapatra, Kavita Gupta, Harisha Dewan, Minu Raju, D Anupama Prasad

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引用次数: 0

Abstract

Objective: This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics.

Materials and methods: Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility was assessed through cell viability, adhesion, and proliferation by using human osteoblast-like cells (MG-63). Statistical analysis was performed using ANOVA and Tukey's HSD test.

Results: Antibiotics showed the highest antibacterial activity. Silver reduced cell viability, adhesion, and proliferation, while chitosan balanced antibacterial efficacy and biocompatibility. Time-dependent viability assays indicated consistent reduction for silver-treated cells.

Conclusion: Silver, chitosan, and antibiotics are effective against implant-related pathogens, but their cytocompatibility varies.

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含抗菌药物种植体涂层的抗菌性能和细胞相容性评估：体外研究。

目的：研究银、壳聚糖和抗生素包被钛种植体的抗菌效果和细胞相容性。材料和方法：采用抑菌带对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌进行抑菌试验。采用人成骨细胞样细胞（MG-63），通过细胞活力、粘附和增殖来评估细胞相容性。统计学分析采用方差分析和Tukey’s HSD检验。结果：抗菌药物抗菌活性最高。银降低了细胞活力、粘附和增殖，而壳聚糖平衡了抗菌效果和生物相容性。时间依赖的活力测定表明，银处理的细胞一致减少。结论：银、壳聚糖和抗生素对种植体相关病原体均有较好的抑制作用，但其细胞相容性存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacy & bioallied sciences

CiteScore

1.40

自引率

0.00%

发文量