Second Primary Tumors After Primary Brain Tumors and Vice Versa: A Single-Center, Retrospective Study.

Meher Angez, Rabeet Tariq, Alveena Zafar, Ali Azan Ahmed, Ayesha Nasir Hameed, Usama Waqar, Syed Ather Enam
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Abstract

Background: Advancements in surgery, chemotherapy, and radiotherapy have improved survival for brain tumor patients, increasing the risk of second primary tumors (SPTs) among long-term survivors. This study examines the types and risks of SPTs in brain tumor patients presenting at a tertiary care hospital.

Methods: This single-center, retrospective study explored occurrences of SPTs following primary brain tumors and occurrences of brain tumors as SPTs following primary extra neural tumors. A total of 41 patients were included and analyzed presenting with histologically confirmed SPTs between 1st January 2000 and 31st December 2020.

Results: The study included 41 patients with SPTs, primarily female (65.9%). Of these, 20 patients (48.7%) developed SPTs after a primary brain tumor, while 21 patients (51.2%) developed brain tumors as SPTs after extra-neural tumors. Among patients who developed SPTs after brain tumors (n=20), meningioma (n=8, 40.0%) and pituitary adenoma (n=6, 30.0%) were the most prevalent first primary tumors (FPTs) while breast tumors predominated as SPTs (n=4, 20.0%). Survival analysis indicated younger mean age (44.5 years) for patients marked alive, compared to those marked deceased (57.0 years) and those with unknown outcomes (63.0 years).

Conclusion: Based on this retrospective analysis, the median age at diagnosis was 44.5 years, with a considerable number of patients (36.6%) having uncertain outcomes at follow-up due to incomplete records. These findings highlight the need for improved follow-up data management to better assess long-term survival in patients with SPTs following brain tumors.

原发性脑肿瘤后继发肿瘤,反之亦然:一项单中心回顾性研究。
背景:手术、化疗和放疗的进步提高了脑肿瘤患者的生存率,增加了长期幸存者发生第二原发肿瘤(SPTs)的风险。本研究探讨了在三级医院就诊的脑肿瘤患者的spt类型和风险。方法:本研究为单中心回顾性研究,探讨原发性脑肿瘤后spt的发生情况,以及原发性神经外肿瘤后脑肿瘤作为spt的发生情况。在2000年1月1日至2020年12月31日期间,共纳入并分析了41例组织学证实的spt患者。结果:本研究纳入41例spt患者,主要为女性(65.9%)。其中,20例患者(48.7%)在原发脑肿瘤后发展为spt, 21例患者(51.2%)在神经外肿瘤后发展为spt。在脑肿瘤后发生SPTs的患者中(n=20),脑膜瘤(n=8, 40.0%)和垂体腺瘤(n=6, 30.0%)是最常见的原发性肿瘤(FPTs),而乳腺肿瘤以SPTs为主(n=4, 20.0%)。生存分析显示,与标记为死亡(57.0岁)和未知结果(63.0岁)的患者相比,标记为活着的患者的平均年龄(44.5岁)更小。结论:基于回顾性分析,诊断时的中位年龄为44.5岁,相当多的患者(36.6%)由于记录不完整,随访结果不确定。这些发现强调需要改进随访数据管理,以更好地评估脑肿瘤后spt患者的长期生存。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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