Seasonal Variation in HLA-B27 Associated Uveitis

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology Pub Date : 2025-02-09 DOI:10.1111/ceo.14503

Priya D. Samalia, James Brodie, Joanne L. Sims, Rachael L. Niederer

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引用次数: 0

Abstract

Background

To examine if there was a monthly variation in HLA-B27-associated uveitis.

Methods

Retrospective review of all individuals presenting to a single centre with HLA-B27-associated uveitis from 2009 to 2020.

Results

577 participants with HLA-B27-associated uveitis were included. The median age at presentation was 40.4 years (IQR 31.1–51.4) and 356 (61.7%) were male. 141 (24.4%) participants were diagnosed with ankylosing spondylitis. The incidence of HLA-B27 uveitis was greatest in August (winter) and lowest in March (autumn). On univariate analysis, there was an inverse relationship between HLA-B27-associated uveitis incidence and mean air temperature (β−2.704, p < 0.001) and sunlight hours (β−0.221, p = 0.003), and a positive relationship between uveitis incidence and rainfall (β 0.324, p = 0.006) and humidity (β 1.741, p = 0.006). On multivariate analysis, there was an inverse relationship with temperature (β−4.846, p = 0.002) and a positive association with humidity (β 2.033, p = 0.008). On multivariate analysis, the impact of rainfall shifted to negative (β−0.446, p = 0.017) and sunlight hours lost significance. The monthly effect was more pronounced for non-Caucasian ethnicities and for those without ankylosing spondylitis.

Conclusion

In New Zealand, HLA-B27-associated uveitis episodes are influenced by monthly changes with higher incidence in winter months.

Abstract Image

查看原文本刊更多论文

HLA-B27相关性葡萄膜炎的季节变化。

背景：研究hla - b27相关性葡萄膜炎是否有月度变化。方法：回顾性分析2009年至2020年在同一中心就诊的所有hla - b27相关葡萄膜炎患者。结果：577例hla - b27相关葡萄膜炎纳入研究。就诊时的中位年龄为40.4岁（IQR为31.1-51.4），其中356例（61.7%）为男性。141名（24.4%）参与者被诊断为强直性脊柱炎。HLA-B27葡萄膜炎的发病率以8月（冬季）最高，3月（秋季）最低。单因素分析显示，hla - b27相关性葡萄膜炎发病率与平均气温呈负相关（β-2.704, p）。结论：在新西兰，hla - b27相关性葡萄膜炎发病率受月变化影响，冬季发病率较高。

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来源期刊

Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

7.60

自引率

12.50%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.