Datta Singh Goolaub, Ye Tian, Joshua F P van Amerom, John Wood, Jon Detterich, Krishna S Nayak, Christopher K Macgowan
{"title":"Multiresolution comparison of fetal real-time and CINE MRI at 0.55T.","authors":"Datta Singh Goolaub, Ye Tian, Joshua F P van Amerom, John Wood, Jon Detterich, Krishna S Nayak, Christopher K Macgowan","doi":"10.1016/j.jocmr.2025.101856","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dynamic fetal cardiovascular MRI (CMR) enables visualization of moving structures to assess congenital heart disease and plan treatment. Low field MRI systems can provide more comfortable platforms for fetal CMR.</p><p><strong>Objectives: </strong>To demonstrate the feasibility and utility of motion corrected fetal cardiac cine CMR and compare it with real-time CMR at multiple spatial resolutions at 0.55T.</p><p><strong>Methods: </strong>10 human pregnancies were scanned at 0.55T (derated Siemens Aera) with spiral steady-state free precession imaging. Real-time images were reconstructed and used for motion correction and fetal cardiac gating followed by cine reconstructions. The signal-to-noise ratio (SNR), image quality, blood-to-myocardium contrast, and contrast-to-noise ratio (CNR) from real-time and cine reconstructions were compared. The effect of acceleration on cine accuracy was assessed by retrospectively undersampling the data and measuring the reconstruction error with the normalized root-mean-squared difference (NRMSD) in 5 fetuses. Reproducibility of the measurements was assessed by reconstructing cines from 2 independent windows of data and computing the NRMSD relative to the reference image in 5 fetuses.</p><p><strong>Results: </strong>The SNR, CNR, and image quality were better for cines than their corresponding real-time reconstructions. The blood-to-myocardium contrast had no significant difference between real-time and cine reconstructions. With finer spatial resolution, real-time images degraded, and cardiac structures were less conspicuous. NRMSD in cines decreased with increasing scan times across all resolutions (NRMSD = 10 ± 2% for 7s scan duration). Good consistency (NRMSD = 11 ± 3%) was achieved between independent reconstruction windows.</p><p><strong>Conclusion: </strong>While this study was performed on an experimental scanner (derated; not commercially available), we have shown that fetal cine CMR is feasible at 0.55T and provide high quality fetal cardiac images at high spatiotemporal resolutions.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101856"},"PeriodicalIF":4.2000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Magnetic Resonance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jocmr.2025.101856","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Dynamic fetal cardiovascular MRI (CMR) enables visualization of moving structures to assess congenital heart disease and plan treatment. Low field MRI systems can provide more comfortable platforms for fetal CMR.
Objectives: To demonstrate the feasibility and utility of motion corrected fetal cardiac cine CMR and compare it with real-time CMR at multiple spatial resolutions at 0.55T.
Methods: 10 human pregnancies were scanned at 0.55T (derated Siemens Aera) with spiral steady-state free precession imaging. Real-time images were reconstructed and used for motion correction and fetal cardiac gating followed by cine reconstructions. The signal-to-noise ratio (SNR), image quality, blood-to-myocardium contrast, and contrast-to-noise ratio (CNR) from real-time and cine reconstructions were compared. The effect of acceleration on cine accuracy was assessed by retrospectively undersampling the data and measuring the reconstruction error with the normalized root-mean-squared difference (NRMSD) in 5 fetuses. Reproducibility of the measurements was assessed by reconstructing cines from 2 independent windows of data and computing the NRMSD relative to the reference image in 5 fetuses.
Results: The SNR, CNR, and image quality were better for cines than their corresponding real-time reconstructions. The blood-to-myocardium contrast had no significant difference between real-time and cine reconstructions. With finer spatial resolution, real-time images degraded, and cardiac structures were less conspicuous. NRMSD in cines decreased with increasing scan times across all resolutions (NRMSD = 10 ± 2% for 7s scan duration). Good consistency (NRMSD = 11 ± 3%) was achieved between independent reconstruction windows.
Conclusion: While this study was performed on an experimental scanner (derated; not commercially available), we have shown that fetal cine CMR is feasible at 0.55T and provide high quality fetal cardiac images at high spatiotemporal resolutions.
期刊介绍：
Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to:
New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system.
New methods to enhance or accelerate image acquisition and data analysis.
Results of multicenter, or larger single-center studies that provide insight into the utility of CMR.
Basic biological perceptions derived by CMR methods.
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