Intestinal Type Sinonasal Adenocarcinoma: A Clinicopathological Study of 48 Patients With Review of Literature.

IF 1 4区 医学 Q4 PATHOLOGY
Nasir Ud Din, Saba Akram, Muhammad Raza, Zubair Ahmad
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引用次数: 0

Abstract

BackgroundIntestinal type sinonasal adenocarcinoma is a gland forming malignant tumor of sinonasal tract which is histologically and immunohistochemically similar to intestinal type adenocarcinomas. Intestinal type sinonasal adenocarcinoma has a well-recognized etiological association with occupational exposure to wood dusts.ObjectiveTo report the clinicopathological factors of intestinal type sinonasal adenocarcinoma and review the published literature.MethodsForty-eight tumors reported as intestinal type sinonasal adenocarcinoma were retrieved and clinicopathological features were noted.ResultsAge ranged from 22 to 79 (mean 44) years with 36 men and 12 women. Most patients were presented with nasal blockage and difficulty in breathing. Occupational exposure to dust was present in the majority of patients. Tumors were composed of papillae or acini lined by dysplastic intestinal type columnar epithelium with interspersed goblet cells. There were 13 well differentiated (low grade) and 35 poorly differentiated (high-grade) tumors. CDX2 and SATB2 were expressed by the tumor cells in most tumors. Follow-up was available in 24 patients (range 3 months to 10 years). Most of the patients received chemo and/or radiotherapy. Metastases occurred in 19 out of 24 patients. Brain metastases were very common. All patients with metastases died of their disease.ConclusionClinical and morphological features in our series were similar to published studies. It is important for pathologists to remember the association of these tumors with occupational exposure to wood dusts and to exclude metastases of intestinal adenocarcinomas when confronted by these tumors in the sinonasal tract.

肠型鼻腺癌48例临床病理分析并文献复习。
背景:肠型鼻窦腺癌是一种由腺形成的鼻窦恶性肿瘤,其组织学和免疫组织化学特征与肠型腺癌相似。肠型鼻腺癌与职业接触木屑有公认的病因学关联。目的:报道肠型鼻腺癌的临床病理因素,并复习已发表的文献。方法:回顾性分析48例肠型鼻窦腺癌的临床病理特征。结果:年龄22 ~ 79岁(平均44岁),男性36例,女性12例。大多数患者出现鼻塞和呼吸困难。大多数患者存在职业性粉尘暴露。肿瘤由乳突或腺泡组成,内衬发育不良的肠型柱状上皮,穿插杯状细胞。高分化(低级别)肿瘤13例,低分化(高级别)肿瘤35例。CDX2和SATB2在大多数肿瘤中由肿瘤细胞表达。随访24例(3个月至10年)。大多数患者接受了化疗和/或放疗。24例患者中有19例发生转移。脑转移非常常见。所有转移的病人都死于他们的疾病。结论:本研究的临床和形态学特征与已发表的研究相似。对于病理学家来说,重要的是要记住这些肿瘤与职业接触木屑的关系,并排除在鼻道遇到这些肿瘤时肠腺癌的转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
198
审稿时长
1 months
期刊介绍: International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).
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