Niraparib-related severe refractory thrombocytopenia in ovarian cancer patients receiving paclitaxel/carboplatin chemotherapy: A report on three cases.

IF 0.9 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Mingtao Chen, Lin Zhou, Huijuan Yang, Mengmeng Wang
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引用次数: 0

Abstract

A characteristic toxicity of niraparib is a decrease in blood platelets (PLT), with an incidence of ~ 34% for grades 3 - 4 conditions. However, exceedingly severe cases have been reported infrequently. This paper describes three patients with acute and refractory severe PLT deficiency due to niraparib administration. The symptom characteristics, treatment course, and outcomes have also been analyzed, and the potential for the involvement of immune-related factors is considered. Therefore, it is recommended to comprehensively assess bone marrow hematopoietic function and high-risk variables before administering niraparib, intensify self-management and monitoring of patients, track changes in indicators, and intervene promptly. Additionally, if standard PLT-elevating therapies are ineffective, early full-dose administration of thrombopoietin receptor agonists, preferably avatrombopag, may be beneficial for reversing PLT loss of control.

卵巢癌紫杉醇/卡铂化疗患者尼拉帕尼相关严重难治性血小板减少3例报告
尼拉帕尼的一个特征性毒性是血小板(PLT)减少,3 - 4级的发生率约为34%。然而,极为严重的病例很少报告。本文报道3例因尼拉帕尼治疗而出现急性难治性重度PLT缺乏的患者。分析了症状特征、治疗过程和结果,并考虑了免疫相关因素参与的可能性。因此,建议在给药前综合评估骨髓造血功能及高危变量,加强患者自我管理和监测,跟踪指标变化,及时干预。此外,如果标准的PLT升高疗法无效,早期全剂量给药血小板生成素受体激动剂,最好是阿伐洛巴,可能有利于逆转PLT失控。
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来源期刊
CiteScore
1.70
自引率
12.50%
发文量
116
审稿时长
4-8 weeks
期刊介绍: The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.
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