Impact of Hyperglycemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S500595

Fanhua Meng, Yuan Zhou, Tong Bao, Yunlei Pang, Qinglei Shao, Lifeng Wang, Jing Zhao, Wenchao Li, Haiyan Xu, Yajun Yang, Bozhou Zhang

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引用次数: 0

Abstract

Purpose: Elevated blood glucose levels may disrupt tear film and meibomian gland function, contributing to dry eye disease (DED) and meibomian gland dysfunction (MGD). This study aimed to explore the relationship between hyperglycemia and DED parameters.

Methods: A cross-sectional study at Chifeng Chaoju Eye Hospital (June-August 2024) included 56 participants with DED symptoms. Tear meniscus height (TMH), non-invasive tear film breakup time (FNIBUT, ANIBUT), bulbar redness, and meibomian gland atrophy (U-LAMG, L-LAMG) were assessed using a non-invasive ocular surface analyzer. Fasting blood glucose levels stratified patients into high (≥7 mmol/l) and normal (<7 mmol/l) groups, and their association with DED parameters was analyzed.

Results: Among 56 patients (mean age 52.5 ± 18.0 years), those with elevated glucose levels (n=28) had more severe DED symptoms (OSDI, p = 0.046), lower TMH, FNIBUT, ANIBUT, and higher bulbar redness scores (all p < 0.05). In contrast, lower glucose levels were associated with greater U-LAMG and L-LAMG atrophy (p < 0.05). Glucose positively correlated with intraocular pressure (IOP), redness, U-LAMG, and L-LAMG but negatively correlated with TMH, FNIBUT, and ANIBUT (all p < 0.05).

Conclusion: Hyperglycemia is linked to impaired tear film stability, meibomian gland function, and DED symptoms. Ocular surface disorders in individuals with diabetes may be prevented by effective glycemic control.

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高血糖对泪膜和睑板腺功能障碍的影响：一项横断面研究。

目的：血糖水平升高可能破坏泪膜和睑板腺功能，导致干眼病（DED）和睑板腺功能障碍（MGD）。本研究旨在探讨高血糖与DED参数之间的关系。方法：在赤峰市超聚眼科医院（2024年6月- 8月）进行横断面研究，纳入56例有DED症状的受试者。采用无创眼表分析仪评估撕裂半月板高度（TMH）、无创撕裂膜破裂时间（FNIBUT、ANIBUT）、球红度、睑板腺萎缩（U-LAMG、L-LAMG）。结果：56例患者（平均年龄52.5±18.0岁）中，血糖水平升高的患者（n=28） DED症状更严重（OSDI, p = 0.046）， TMH、FNIBUT、ANIBUT较低，球红评分较高（均p < 0.05）。相反，低葡萄糖水平与U-LAMG和L-LAMG的萎缩有关（p < 0.05）。血糖与眼压（IOP）、红度、U-LAMG、L-LAMG呈正相关，与TMH、FNIBUT、ANIBUT呈负相关（均p < 0.05）。结论：高血糖与泪膜稳定性、睑板腺功能受损和DED症状有关。糖尿病患者的眼表疾病可以通过有效的血糖控制来预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.