Wearable epidermal sensor patch with biomimetic microfluidic channels for fast and time-sequence monitoring of sweat glucose and lactate.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-05-15 Epub Date: 2025-02-01 DOI:10.1016/j.talanta.2025.127683

Chenchen Liao, Shuyi Li, Chaohuan Yang, Chengyu Du, Hecheng Yao, Zhiwu Han, Urszula Stachewicz, Yan Liu

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引用次数: 0

Abstract

Wearable sweat sensors enable non-invasive tracking and monitoring of human physiological information, which is expected to attract wide interest and rapid development in dietary health management and disease prevention. Unfortunately, sweat sensors are limited by rapid evaporation and low secretion rates of sweat. Herein, a sweat detection patch is proposed, which integrates bionic microchannels and multiparameter electrochemical sensors. The microfluidic channel (5°), which mimics ginkgo biloba veins, provided a 40 % higher flow rate compared to the normal channel (0°). Combined with burst pressure, the bionic channel enabled unidirectional transport of 6 μL sweat, effectively avoiding the mixing of old and new sweat. The electrochemical sensors possessed excellent specificity recognition, stability and durability, and have been used to detect substances in sweat, in particular to analyze changes in glucose concentration at different dietary intakes and changes in lactate metabolism after exercise. The rapid collection effect of the microchannels on trace sweat and the fast response of sensors have broad application prospects in real-time human health monitoring.

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.