Impaired 2.5-Hz auditory steady-state response in schizophrenia

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-02-07 DOI:10.1016/j.brainres.2025.149503

Wenpeng Hou , Xiangqin Qin , Yanbing Xiong , Yujie Wen , Yuan Zhou , Fuchun Zhou , Xianbin Li , Chuanyue Wang

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引用次数: 0

Abstract

Background

Delta-band (1–4 Hz) oscillation contributes to speech recognition and may be impaired in schizophrenia. This study primarily aimed to investigate the impairment of the 2.5-Hz auditory steady-state response (ASSR) and its correlation with other auditory cognitive indicators, clinical symptoms, and multidomain cognition in individuals with schizophrenia.

Methods

In this cross-sectional study, 30 patients with schizophrenia and 30 healthy controls underwent 2.5- and 40-Hz ASSR and mismatch negativity (MMN) assessment. The Positive and Negative Syndrome Scale (PANSS) was utilized to assess the patients’ clinical symptoms, and the MATRICS consensus cognitive battery (MCCB) was used to evaluate cognitive function.

Results

The 2.5-Hz ASSR inter-trial coherence (ITC) was significantly lower among patients with schizophrenia than among healthy controls (P = 0.012, Cohen’s d = 0.66). The 2.5-Hz ASSR ITC alone distinguished these groups, with 53.3 % sensitivity, 70.0 % specificity, and 61.7 % accuracy. In the schizophrenia group, the 2.5-Hz ASSR ITC did not correlate significantly with the MMN amplitude or any clinical symptoms or cognitive measurement. In healthy controls, the 2.5-Hz ASSR ITC correlated positively with verbal learning (r = 0.381, P = 0.038), although this correlation was not significant after Bonferroni correction.

Conclusion

The evoked activity maintaining delta-band oscillation entrainment in the auditory system reveals a deficit in schizophrenia and is valuable for the objective diagnosis of this disorder.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.