Abnormal functional connectivity in the frontal hub regions of patients with primary insomnia: a resting-state functional magnetic resonance imaging study.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Acta radiologica Pub Date : 2025-04-01 Epub Date: 2025-02-09 DOI:10.1177/02841851241310398
Zhongyan Wang, Haiyan Qian, Mi Shen, Jianwei Huo, Na Dai, Qingnan Fu, BinBin Sui
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引用次数: 0

Abstract

BackgroundPrimary insomnia (PI) is one of the most common sleep disorders. Diagnosis of insomnia is mainly based on subjective sleep difficulties, and it is still necessary to find objective neurobiological markers.PurposeTo investigate the functional connectivity (FC) of frontal hub regions important for PI.Material and MethodsWe enrolled 20 patients (5 men, 15 women) with PI and 20 controls (5 men, 15 women), matching age, sex. We used resting-state functional magnetic resonance imaging (fMRI) and voxel-mirrored homotopic connectivity (VMHC) to analyze the abnormal changes of FC in the frontal lobe of PI patients.ResultsCompared to controls, abnormal FC regions were mainly concentrated in the superior frontal gyrus (L/R), middle frontal gyrus (L/R), and inferior frontal gyrus (L) of the orbital region and the inferior frontal gyrus of the opercular region (L) (P < 0.05). The VMHC results showed abnormal FC in the middle frontal gyrus of the orbital region (GFR correction, voxel P < 0.01, cluster P < 0.025) in PI patients. The FC between the orbitofrontal gyrus and the inferior frontal gyrus of the opercular region with the frontal gyrus of the medial orbital region demonstrated a significant correlation with the clinical scale (p < 0.05).ConclusionOur study identified abnormal FC, which was mainly located in the orbitofrontal gyrus and the inferior frontal gyrus of the opercular region, in the frontal lobe of patients with insomnia using resting-state fMRI. This is helpful to understand the abnormal neural activity mechanism of insomnia in the frontal lobe and provide a relatively accurate brain region basis for future prevention, diagnosis, and treatment.

原发性失眠症患者额叶中枢区域功能连接异常:静息状态功能磁共振成像研究
背景:原发性失眠(PI)是最常见的睡眠障碍之一。失眠的诊断主要基于主观的睡眠困难,仍然需要寻找客观的神经生物学标志物。目的:探讨脑额轮毂区功能连通性(FC)对脑梗死的影响。材料和方法:我们招募了20例PI患者(5男,15女)和20例对照组(5男,15女),年龄,性别相匹配。我们采用静息状态功能磁共振成像(fMRI)和体素镜像同位连通性(VMHC)分析PI患者额叶FC的异常变化。结果:与对照组相比,FC异常区域主要集中在额上回(L/R)、额中回(L/R)、眶区额下回(L)和眼区额下回(L) (P P P P)。结论:本研究通过静息状态fMRI发现失眠患者额叶FC异常主要位于眶额回和眼区额下回。这有助于了解额叶失眠的异常神经活动机制,为今后的预防、诊断和治疗提供较为准确的脑区依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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