MRI Measures of Fat Distribution and Risk of Cancer.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-04-03 DOI:10.1158/1055-9965.EPI-24-1267

Rita Peila, Thomas E Rohan

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引用次数: 0

Abstract

Background: Excess adiposity has been associated with an increased risk of several types of cancer. The relationship between fat tissue distribution in the body and these outcomes is less well known. Using data from the UK Biobank imaging substudy, we evaluated the prospective relationship between MRI-derived measurements of adipose tissue distribution and the risk of the major site-specific cancers associated with obesity.

Methods: Between 2014 and 2023, MRI measurements on adipose tissue distribution and volume were obtained from 49,044 (52.2% women) cancer-free UK Biobank participants. Quantitative MRI data included volumes of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT), total abdominal fat/height squared (TAT/h2), and muscle fat infiltration (MFI). Cox proportional hazard models adjusted for cancer-specific risk factors were used to generate HRs and 95% confidence intervals.

Results: Incident cancer cases of the breast (N = 179), endometrium (n = 30), colorectum (n = 145), and kidney (n = 50) were ascertained over a median follow-up of 4.5 years. In women, VAT, TAT/h2, and MFI were positively associated with a risk of postmenopausal breast cancer, and ASAT was associated with an increased risk of endometrial cancer. In men, VAT and TAT/h2 were positively associated with a risk of colorectal cancer, whereas ASAT was associated with an increased risk of kidney cancer.

Conclusions: The present study showed that increasing volumes of VAT, ASAT, and MFI were associated with cancers at specific organ sites, indicating a potential role for adipose tissue distribution in influencing cancer risk.

Impact: Both visceral and subcutaneous fat may have an impact on the risk of certain cancers.

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磁共振成像测量脂肪分布和癌症风险。

背景：过度肥胖与几种癌症的风险增加有关。体内脂肪组织分布与这些结果的关系尚不清楚。使用来自英国生物银行成像亚研究的数据，我们评估了脂肪组织分布的mri测量与肥胖相关的主要部位特异性癌症风险之间的前瞻性关系。方法在2014年至2023年期间，从49044名无癌UK Biobank参与者（52.2%为女性）中获得脂肪组织分布和体积的MRI测量结果。定量MRI数据包括内脏和皮下脂肪组织体积（VAT和ASAT）、腹部总脂肪/高度平方（TAT/h2）和肌肉脂肪浸润（MFI）。采用针对癌症特异性危险因素调整的Cox比例风险模型生成风险比（hr）和95%置信区间（CI）。结果乳腺癌（179例）、子宫内膜癌（30例）、结直肠癌（145例）和肾癌（50例）的发病率在中位随访时间为4.5年。在女性中，VAT、TAT/h2和MFI与绝经后乳腺癌风险呈正相关，ASAT与子宫内膜癌风险增加相关。在男性中，VAT和TAT/h2与结直肠癌风险呈正相关，而ASAT与肾癌风险增加相关。本研究表明，VAT、ASAT和MFI体积的增加与特定器官部位的癌症有关，表明脂肪组织分布在影响癌症风险中的潜在作用。内脏脂肪和皮下脂肪都可能对某些癌症的风险有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.