Pd/C-Catalyzed Tandem Synthesis of β-Amino Alcohol Using Epoxide through Transfer Hydrogenation of Nitroarene with Methanol.

Abstract

Using commercially available Pd/C as a catalyst, β-amino alcohols are synthesized from nitroarenes and 1,2-epoxides. Nitroarenes are transformed to amines through ring opening of epoxides and transfer hydrogenation of methanol over the Pd/C catalyst, producing β-amino alcohols. This approach generates aniline in situ from nitrobenzene, making it a viable alternative to traditional β-amino alcohol synthesis procedures. This technique has advantages, including easy recovery of catalysts through filtration and elimination of the requirement for intermediate separation.