Yanqiong Zhang, Qinyue Tao, Qiang Li, Zewei Jin, Dr. Yang Long, Prof. Dr. Xiangge Zhou
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引用次数: 0
Abstract
Transition metal-catalyzed cross-coupling reactions have emerged as one of the most attractive methods in organic synthesis in recent years. However, due to the inertness of C−C bonds, C−C bond activation enabled cross-coupling reactions are far less common. In this work, the first example of palladium-catalyzed cross-coupling of ynones with aryl bromides for the synthesis of diarylacetylenes via C(O)-C(sp) bond activation was described. The reaction exhibited directing group-free unstrained C−C bond activation, wide substrate scope, and good functional group tolerance. Preliminary mechanistic studies suggested that a cross-electrophile coupling reaction pathway might be involved rather than the conventional nucleophilic addition/β-C elimination pathway.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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