Facile Incorporation of the Trioxosulfate Ion Preservative as a Novel Sulfonated Isoindole Fluorescent Marker for Sustainable Determination of an Antidiabetic Alogliptin Drug; Method's Sustainability Evaluation

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2025-02-10 DOI:10.1002/bio.70100

Badriah Saad Al-Farhan, Safaa F. Saleh, Afnan S. Batubara, Dalin A. Hassan, Nujud Maslamani, Deena Mohammed Bukhary, Ahmed Abdulhafez Hamad

{"title":"Facile Incorporation of the Trioxosulfate Ion Preservative as a Novel Sulfonated Isoindole Fluorescent Marker for Sustainable Determination of an Antidiabetic Alogliptin Drug; Method's Sustainability Evaluation","authors":"Badriah Saad Al-Farhan, Safaa F. Saleh, Afnan S. Batubara, Dalin A. Hassan, Nujud Maslamani, Deena Mohammed Bukhary, Ahmed Abdulhafez Hamad","doi":"10.1002/bio.70100","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The proposed study uses a special procedure to verify that an analyte assessment operation is sustainable and environmentally friendly. When the targeted analyte molecule (alogliptin drug, ALT) lacks chromophoric or fluorogenic groups, it cannot be analyzed without marking or structural amendment. The obeyed phenomenon (marking process) could be achieved via fluorescence probing or marking using tagging agents. An innovative reagent pair consisting of trioxosulfate ion and <i>o</i>-Phthaldialdehyde (OPD) is used in the described analytical approach. This reagent is used to build a novel fluorescent nucleus and can be detected using the developed fluorimetric approach. ALT's amino moiety could condense trioxosulfate/OPD. This study presents a new, facile, green, sustainable fluorometric assay of the ALT drug. The product's response is linear at 50.00–800.00 ng mL<sup>−1</sup> concentration range (LOD = 15.74 and LOQ = 47.69 ng mL<sup>−1</sup>). The method validation was considered following the International Council for Harmonisation (ICH) recommendations. The planned probe was applied to the crude powder and dose forms, and excipients had no influence. The planned analytical procedure is identified as sustainable and white by the WAC (White Analytical Chemistry) indications following the Green/Red/Blue (RGB 12) pattern. Additionally, new tools (BAGI and GSST) were applied to the current work.</p>\n </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Luminescence","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bio.70100","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

The proposed study uses a special procedure to verify that an analyte assessment operation is sustainable and environmentally friendly. When the targeted analyte molecule (alogliptin drug, ALT) lacks chromophoric or fluorogenic groups, it cannot be analyzed without marking or structural amendment. The obeyed phenomenon (marking process) could be achieved via fluorescence probing or marking using tagging agents. An innovative reagent pair consisting of trioxosulfate ion and o-Phthaldialdehyde (OPD) is used in the described analytical approach. This reagent is used to build a novel fluorescent nucleus and can be detected using the developed fluorimetric approach. ALT's amino moiety could condense trioxosulfate/OPD. This study presents a new, facile, green, sustainable fluorometric assay of the ALT drug. The product's response is linear at 50.00–800.00 ng mL⁻¹ concentration range (LOD = 15.74 and LOQ = 47.69 ng mL⁻¹). The method validation was considered following the International Council for Harmonisation (ICH) recommendations. The planned probe was applied to the crude powder and dose forms, and excipients had no influence. The planned analytical procedure is identified as sustainable and white by the WAC (White Analytical Chemistry) indications following the Green/Red/Blue (RGB 12) pattern. Additionally, new tools (BAGI and GSST) were applied to the current work.

Abstract Image

查看原文本刊更多论文

新型磺化异吲哚荧光标记物在抗糖尿病药物阿格列汀检测中的应用方法的可持续性评价

拟议的研究使用一种特殊程序来验证分析物评估操作是可持续的和环境友好的。当目标分析物分子（阿格列汀药物、ALT）缺乏显色性或荧光性基团时，不进行标记或结构修改就无法进行分析。所服从的现象（标记过程）可以通过荧光探测或标记剂来实现。一种由三氧硫酸盐离子和邻苯二醛（OPD）组成的创新试剂对被用于描述的分析方法。该试剂被用来建立一个新的荧光核，并可以使用开发的荧光法检测。ALT的氨基部分可以凝聚三氧硫酸酯/OPD。本研究提出了一种新的、简便的、绿色的、可持续的ALT药物荧光测定方法。产品在50.00 ~ 800.00 ng mL−1浓度范围内呈线性（LOD = 15.74, LOQ = 47.69 ng mL−1）。该方法验证是按照国际统一理事会（ICH）的建议进行的。所设计的探针应用于粗粉剂和剂型，辅料对其无影响。按照绿/红/蓝（RGB 12）模式，计划的分析程序被WAC（白色分析化学）标识为可持续和白色。此外，新的工具（BAGI和GSST）应用于当前的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.