Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT-BD Study

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-02-09 DOI:10.1002/brb3.70297

José Etxaniz-Oses, Sara Maldonado-Martín, Inaki Zorrilla, Ilargi Gorostegi-Anduaga, Maria J. Apodaca-Arrizabalaga, Ana González-Pinto

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Abstract

Introduction

Bipolar disorder (BD) is associated with considerable morbidity and premature mortality, mainly due to somatic causes. This study aims to determine some physical, exercise capacity–related physiological variables and biochemical markers of health status in adults (45.4 ± 13.1 years) with BD (n = 65) compared to a healthy control (HC) population (n = 29) sample and to estimate cardiovascular risk (CVR) through different methods in the BD group.

Methods

Multiple assessments included body composition, cardiorespiratory fitness (CRF), and biochemical parameters. CVR was calculated using the Framingham Heart Study, SCORE2, and relative risk methods.

Results

The BD population, compared to the HC, showed unfavorable body composition (waist-to-hip ratio, 0.9 ± 0.1 vs. 0.8 ± 0.1; fat body mass, 33.3 ± 10.2 vs. 24.3 ± 8.9%, p ≤ 0.001), CRF (peak oxygen uptake, 25.2 ± 8.2 vs. 33.4 ± 8.7 mL kg⁻¹ min⁻¹; and cardiorespiratory optimal point, 27.9 ± 4.2 vs. 23.6 ± 4.2 ventilation/oxygen uptake ratio, p ≤ 0.05), biochemical concentrations of atherogenic indexes (total cholesterol/high-density lipoprotein cholesterol ratio, 4.1 ± 1.5 vs. 3.3 ± 1.0; and triglycerides/high-density lipoprotein cholesterol ratio, 2.8 ± 2.3 vs. 1.5 ± 1.0, p ≤ 0.05), and inflammatory C-reactive protein (3.8 ± 10.2 vs. 0.9 ± 1.05 mg/dL, p ≤ 0.05). Consequently, CVR showed higher values (p ≤ 0.05) in BD (high risk, 3.1%) compared to HC (low-to-moderate risk, 2.2%) participants, according to SCORE2, higher (p ≤ 0.05) vascular age (49.8 years) than chronological age (45.8 years), with a significant difference (p = 0.005) compared to HC.

Conclusions

This study highlights the importance of specific physical, biochemical, and physiological screening and CVR and vascular age assessment for people with BD. The practical application of these findings would prevent cardiovascular disease in BD and promote a healthier lifestyle as an adjuvant strategy to pharmacological intervention.

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成年双相情感障碍患者因其生理、生化和生理特征而增加心血管风险吗？FINEXT-BD研究

双相情感障碍（BD）与相当高的发病率和过早死亡相关，主要是由于躯体原因。本研究旨在确定成年（45.4±13.1岁）BD患者（n = 65）与健康对照组（n = 29）相比的一些身体、运动能力相关的生理变量和健康状况的生化指标，并通过不同的方法估计BD组的心血管风险（CVR）。方法采用体成分、心肺适能（CRF）、生化指标等多种评价方法。CVR采用Framingham Heart Study、SCORE2和相对风险方法计算。结果与HC相比，BD人群显示出不利的身体组成(腰臀比，0.9±0.1 vs 0.8±0.1；脂肪体质量，33.3±10.2 vs. 24.3±8.9%,p≤0.001)，CRF(峰值摄氧量，25.2±8.2 vs. 33.4±8.7 mL kg - 1 min - 1；而心肺最佳点，27.9±4.2 vs. 23.6±4.2通气/吸氧比，p≤0.05)，致动脉粥样硬化指标生化浓度(总胆固醇/高密度脂蛋白胆固醇比，4.1±1.5 vs. 3.3±1.0；甘油三酯/高密度脂蛋白胆固醇比值（2.8±2.3 vs. 1.5±1.0,p≤0.05），炎性c反应蛋白（3.8±10.2 vs. 0.9±1.05 mg/dL, p≤0.05）。因此，根据SCORE2，与HC（低至中等风险，2.2%）参与者相比，BD（高风险，3.1%）参与者的CVR值更高（p≤0.05），血管年龄（49.8岁）高于实足年龄（45.8岁），与HC相比差异显著（p = 0.005）。结论本研究强调了对双相障碍患者进行特定的物理、生化和生理筛查以及CVR和血管年龄评估的重要性，这些发现的实际应用将有助于预防双相障碍患者的心血管疾病，促进更健康的生活方式，作为药物干预的辅助策略。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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