Multi-Plant Concentrated Powder Improved Skin Whitening: A Double-Blinded, Randomized, and Placebo-Controlled Clinical Study

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-02-10 DOI:10.1111/jocd.70011

Yuxiang He, Yongshi Bu, Chi-Fu Chiang, Yung-Hsiang Lin, Chia-Hua Liang, Leong-Perng Chan, Jiawen Sun

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引用次数: 0

Abstract

Introduction

With the growing demand for skin-enhancing products in the market, research into edible plants has expanded significantly. Numerous studies have shown that plant extracts rich in phytochemicals can effectively improve skin issues such as wrinkles, pigmentation, and dullness. However, clinical studies focusing on the effects of combined ingredients are still limited.

Objective

This study combined three plant ingredients known for their skin-beautifying effects and clinically tested their functional properties.

Methods

Sixty healthy subjects were screened and randomly divided into two groups: a test group (TG) and a placebo group (PG). TG took two tablets of multi-plant concentrated powder daily, while PG took placebo tablets without active ingredients. The study lasted 12 weeks. Plasma Trolox equivalent antioxidant capacity (TEAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured at week 0 (W0), week 8 (W8), and week 12 (W12). Skin brightness (L* value), skin tone (Individual Typological Angle (ITA°)), erythema (a* value), skin spots, and wrinkles were assessed at week 0 (W0), week 4 (W4), week 8 (W8), and week 12 (W12).

Results

The study showed significant improvements in all three antioxidant markers in the blood after consuming the compound ingredient tablets compared to the PG (p < 0.01). L* value and ITA° significantly increased from 8 weeks (p < 0.1). Skin spots significantly decreased at W8 and W12 (p < 0.1). While a* value and skin wrinkles showed noticeable reductions within the group in week 12 (p < 0.1), there were no significant differences compared to the PG.

Conclusions

Consumption of multi-plant concentrated powder improved skin whitening, brightened skin tone, reduced skin spots, and showed some improvement in wrinkles and erythema.

Trial Registration

ClinicalTrials.gov identifier: NCT05988567

Abstract Image

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多植物浓缩粉剂改善皮肤美白：一项双盲、随机、安慰剂对照的临床研究

随着市场对增肤产品的需求不断增长，对可食用植物的研究也显著扩大。大量研究表明，富含植物化学物质的植物提取物可以有效改善皮肤问题，如皱纹、色素沉着和暗沉。然而，针对联合用药效果的临床研究仍然有限。目的本研究结合三种具有美容功效的植物成分，并对其功能特性进行临床试验。方法筛选60名健康受试者，随机分为试验组（TG）和安慰剂组（PG）。TG每天服用2片多植物浓缩粉，PG服用无活性成分的安慰剂片。研究持续了12周。在第0周（W0）、第8周（W8）和第12周（W12）测定血浆Trolox当量抗氧化能力（TEAC）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）。在第0周（W0）、第4周（W4）、第8周（W8）和第12周（W12）评估皮肤亮度（L*值）、肤色（个体类型角度（ITA°））、红斑（a*值）、皮肤斑点和皱纹。结果与PG组相比，服用复方成分片后血中3种抗氧化指标均有显著改善（p < 0.01）。L*值和ITA°较8周显著升高（p < 0.1）。皮肤斑点在W8和W12时显著减少（p < 0.1）。虽然a*值和皮肤皱纹在第12周组内明显减少（p < 0.1），但与PG相比无显著差异。结论多植物浓缩粉的消费改善了皮肤美白，肤色变亮，皮肤斑点减少，皱纹和红斑也有所改善。试验注册ClinicalTrials.gov识别码：NCT05988567

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.