Age-dependent influence of T wave amplitude on short period temporal dispersion in healthy subjects

IF 1.3 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of electrocardiology Pub Date : 2025-02-03 DOI:10.1016/j.jelectrocard.2025.153883

Gianfranco Piccirillo , Federica Moscucci , Martina Mezzadri , Cristina Caltabiano , Giovanni Cisaria , Guendalina Vizza , Valerio De Santis , Marco Giuffrè , Sara Stefano , Claudia Scinicariello , Ilaria Lospinuso , Susanna Sciomer , Pietro Rossi , Giovambattista Desideri

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引用次数: 0

Abstract

Background

T wave amplitude and repolarization variability in ECG showed inverse correlations. Sympathetic activation, induced by head-up tilt, is associated to a reduced T wave amplitude.

Methods

Noninvasive hemodynamic and ECG data from three healthy subjects' groups (Group 1: 10–19 years-old; Group 2: 40–49 years-old; Group 3: 80–89 years-old) were analyzed. Measurements were taken during controlled-breathing rest, and during head-up tilt. The mean and standard deviation (_SD) were calculated for these ECG intervals: QT, STp (from S to Tpeak) and Te (from Tpeak to Tend). Results: During tilt, a significant decrease in T wave amplitude was observed in the younger groups (p < 0.001), but not in Group 3. At rest, Group 1 exhibited higher voltage compared to Group 2 (p < 0.05) and 3 (p < 0.001), as Group 2 compared to Group 3 (p < 0.05). A negative correlation was confirmed between T wave amplitude and QT_SD, STp_SD and Te_SD (p < 0.001). Low-frequency normalized units (p < 0.05) and high-frequency normalized units (p < 0.001) were inversely related to T-wave amplitude.

Conclusion

The findings suggest an age-dependent decline in T wave amplitude during tilt and elucidates the relationship between systolic function and T wave amplitude among healthy subjects. These insights warrant further investigations in clinical and research settings for cardiovascular diseases.

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来源期刊

Journal of electrocardiology 医学-心血管系统

CiteScore

2.70

自引率

7.70%

发文量

152

审稿时长

38 days

期刊介绍： The Journal of Electrocardiology is devoted exclusively to clinical and experimental studies of the electrical activities of the heart. It seeks to contribute significantly to the accuracy of diagnosis and prognosis and the effective treatment, prevention, or delay of heart disease. Editorial contents include electrocardiography, vectorcardiography, arrhythmias, membrane action potential, cardiac pacing, monitoring defibrillation, instrumentation, drug effects, and computer applications.