Sustainable lipid production by oleaginous yeasts: Current outlook and challenges

IF 9.7 1区环境科学与生态学 Q1 AGRICULTURAL ENGINEERING

Bioresource Technology Pub Date : 2025-02-07 DOI:10.1016/j.biortech.2025.132205

Kukkala Kiran Kumar , Farha Deeba , Ajay Kumar Pandey , Asimul Islam , Debarati Paul , Naseem A. Gaur

{"title":"Sustainable lipid production by oleaginous yeasts: Current outlook and challenges","authors":"Kukkala Kiran Kumar , Farha Deeba , Ajay Kumar Pandey , Asimul Islam , Debarati Paul , Naseem A. Gaur","doi":"10.1016/j.biortech.2025.132205","DOIUrl":null,"url":null,"abstract":"<div><div>Yeast lipid has gained prominence as a sustainable energy source and so various oleaginous yeasts are being investigated to create efficient lipogenic platforms. This review aims to assess the various biotechnological strategies for enhanced production of yeast lipids via agro-waste processing and media engineering including multiomic analyses, genetic engineering, random mutagenesis, and laboratory adaptive evolution. The review also emphasizes the role of cutting-edge omics technologies in pinpointing differentially expressed genes and enriched networks crucial for designing advanced metabolic engineering strategies for prominent oleaginous yeast species. The review addresses the challenges and future prospects of a viable lipid production industry that is possible through advancements in current technologies, strain improvement, media optimization and techno-economic and life cycle analyses at lab, pilot and industrial scales. This review comprehensively provides deep insights for enhancement of yeast lipid biosynthesis to reach industrially benchmarked standard of a lipid production platform.</div></div>","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":"421 ","pages":"Article 132205"},"PeriodicalIF":9.7000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioresource Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0960852425001713","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURAL ENGINEERING","Score":null,"Total":0}

引用次数: 0

Abstract

Yeast lipid has gained prominence as a sustainable energy source and so various oleaginous yeasts are being investigated to create efficient lipogenic platforms. This review aims to assess the various biotechnological strategies for enhanced production of yeast lipids via agro-waste processing and media engineering including multiomic analyses, genetic engineering, random mutagenesis, and laboratory adaptive evolution. The review also emphasizes the role of cutting-edge omics technologies in pinpointing differentially expressed genes and enriched networks crucial for designing advanced metabolic engineering strategies for prominent oleaginous yeast species. The review addresses the challenges and future prospects of a viable lipid production industry that is possible through advancements in current technologies, strain improvement, media optimization and techno-economic and life cycle analyses at lab, pilot and industrial scales. This review comprehensively provides deep insights for enhancement of yeast lipid biosynthesis to reach industrially benchmarked standard of a lipid production platform.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioresource Technology 工程技术-能源与燃料

CiteScore

20.80

自引率

19.30%

发文量

2013

审稿时长

12 days

期刊介绍： Bioresource Technology publishes original articles, review articles, case studies, and short communications covering the fundamentals, applications, and management of bioresource technology. The journal seeks to advance and disseminate knowledge across various areas related to biomass, biological waste treatment, bioenergy, biotransformations, bioresource systems analysis, and associated conversion or production technologies. Topics include: • Biofuels: liquid and gaseous biofuels production, modeling and economics • Bioprocesses and bioproducts: biocatalysis and fermentations • Biomass and feedstocks utilization: bioconversion of agro-industrial residues • Environmental protection: biological waste treatment • Thermochemical conversion of biomass: combustion, pyrolysis, gasification, catalysis.