Considerations on risk mitigating strategies for bacterial contamination of platelet concentrates – The Dutch perspective

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2025-02-04 DOI:10.1016/j.transci.2025.104087

Pieter F. van der Meer , Vĕra M.J. Novotny , Thomas L.R. Klei

引用次数: 0

Abstract

Due to their storage at room temperature, platelet concentrates are at risk for bacterial outgrowth if the unit is contaminated. Nowadays, various mitigation strategies are available, including bacterial screening and pathogen inactivation. Since pathogen inactivation technologies impact the clinical efficacy of the platelets, including but not limited to lower increments after transfusion and more significant bleeding, a balance needs to be struck between the safety and efficacy of platelet transfusions. In this Brief Review, we discuss the current situation in the Netherlands.

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考虑血小板浓缩物细菌污染的风险减轻策略-荷兰的观点

由于血小板浓缩物是在室温下储存的，如果浓缩物被污染，就有细菌生长的危险。目前，各种缓解策略可用，包括细菌筛选和病原体灭活。由于病原体灭活技术会影响血小板的临床疗效，包括但不限于输血后血小板增量降低和出血更严重，因此需要在血小板输注的安全性和有效性之间取得平衡。在这篇简短的综述中，我们讨论了荷兰的现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.