Chiral Inorganic Nanomaterial-Based Diagnosis and Treatments for Neurodegenerative Diseases

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-02-09 DOI:10.1002/adma.202418723

Jingqi Dong, Liguang Xu, Aihua Qu, Changlong Hao, Maozhong Sun, Chuanlai Xu, Shudong Hu, Hua Kuang

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Abstract

Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of chiral nanomaterials in bioengineering and medicine. In this review, the basic principles of constructing chiral nanomaterials along with the latest progress in research are comprehensively summarized. Then, the application of chiral nanomaterials for the diagnosis of neurodegenerative diseases (NDDs) is systematically described. In addition, the significant potential and broad prospects of chiral nanomaterials in the treatment of NDDs are highlighted from several aspects, including the disaggregation of neurofibrils, the scavenging of reactive oxygen species, regulation of the microbial–gut–brain axis, the elimination of senescent cells, and the promotion of directed differentiation in neural stem cells. Finally, a perspective of the challenges and future development of chiral nanomaterials for the treatment of NDDs is provided.

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基于手性无机纳米材料的神经退行性疾病的诊断和治疗

近几十年来，手性纳米材料因其生物相容性和独特的手性效应而受到广泛的研究。这些关键特性极大地促进了手性纳米材料在生物工程和医学领域的快速发展。本文综述了构建手性纳米材料的基本原理和最新研究进展。然后，系统介绍了手性纳米材料在神经退行性疾病诊断中的应用。此外，从神经原纤维的分解、活性氧的清除、微生物-肠-脑轴的调节、衰老细胞的消除以及促进神经干细胞的定向分化等几个方面，强调了手性纳米材料在治疗nds方面的巨大潜力和广阔前景。最后，对手性纳米材料治疗ndd的挑战和未来发展进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.