Relationship between the ultrasound features of different molecular subtypes of breast cancer and positive PD-1/PD-L1 expression.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Ruiqian Yan, Haixia Li, Junxi Gao
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引用次数: 0

Abstract

Objectives: To analyze differences in programmed cell death protein 1/ligand 1 (PD-1/PD-L1) expression, as well as the relationships between ultrasound/contrast-enhanced ultrasound characteristics and PD-1/PD-L1 expression, among invasive breast cancer molecular subtypes.

Methods: The study included 172 invasive breast cancer patients with surgical resection and pathological confirmation at the First Affiliated Hospital of Xinjiang Medical University from June 2016 to April 2022. PD-1/PD-L1 expression was detected by immunohistochemistry. All patients underwent conventional ultrasound and some underwent contrast-enhanced ultrasound examination before resection.

Results: PD-1 and PD-L1 were expressed in 112 and 121 cases, respectively. The luminal B and HER-2 subtypes had the lowest and highest PD-1 expression rates, respectively. The luminal B and triple-negative subtypes had the lowest and highest PD-L1 expression rates, respectively. Among 112 PD-1-positive cases, most luminal B cases exhibited ill-defined margins, while distant metastasis was more common in triple-negative cases. Among 121 PD-L1-positive cases, many HER-2-positive and triple-negative cases presented as large masses (diameter ≥ 2 cm), while luminal B cases were more likely to show calcification. Most luminal B PD-L1-positive cases displayed indistinct margins on contrast-enhanced ultrasound.

Conclusions: PD-1 expression differed among molecular subtypes of invasive breast cancer. Ultrasound/contrast-enhanced ultrasound features correlated with PD-1/PD-L1 expression in different breast cancer subtypes.

乳腺癌不同分子亚型超声特征与PD-1/PD-L1阳性表达的关系
目的:分析浸润性乳腺癌分子亚型中程序性细胞死亡蛋白1/配体1 (PD-1/PD-L1)表达的差异,以及超声/增强超声特征与PD-1/PD-L1表达的关系。方法:选取2016年6月至2022年4月在新疆医科大学第一附属医院行手术切除并病理证实的浸润性乳腺癌患者172例。免疫组织化学检测PD-1/PD-L1的表达。所有患者术前均行常规超声检查,部分患者术前行超声造影检查。结果:PD-1和PD-L1分别在112例和121例中表达。luminal B和HER-2亚型的PD-1表达率分别最低和最高。luminal B亚型和三阴性亚型的PD-L1表达率分别最低和最高。在112例pd -1阳性病例中,大多数腔内B癌表现为边缘不清,而远端转移在三阴性病例中更为常见。121例pd - l1阳性病例中,许多her -2阳性和三阴性病例表现为大肿块(直径≥2 cm),而luminal B病例更多表现为钙化。大多数腔内B - pd - l1阳性病例超声造影显示边缘不清。结论:PD-1在浸润性乳腺癌分子亚型中的表达存在差异。超声/超声增强特征与不同乳腺癌亚型中PD-1/PD-L1表达相关
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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