Seroprevelance of Dengue Among Healthy Blood Donors in Blood bank.

Q3 Medicine

Journal of Nepal Health Research Council Pub Date : 2024-12-20

Jyotshna Sapkota, Ranjan Thapa, Basudha Nepal, Ram Prasad Adhikari, Sushila Khadka, Kiran Aryal, Avinav Acharya, Saroj Kunwar, Laxmi Kant Khanal

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引用次数: 0

Abstract

Background: Dengue is a viral infection, commonly found in tropical and subtropical regions across the globe particularly in urban and semi-urban settings. There has been significant increase in dengue cases over past two decades. This study aims to determine the prevalence of dengue NS1 antigen, IgM, and IgG antibodies among healthy blood donors at the Nepal Medical College Blood Bank.

Methods: The descriptive cross-sectional study was carried out at the blood bank of Nepal Medical College between August to November 2023. Ethical approval was received from the Institutional Review Committee of Nepal Medical College (Ref: -080/081). Two hundred and thirty two serum samples from the healthy blood donors were screened with Dengue RDT (SD Bioline Dengue Duo) for detection of NS1 antigen, IgM and Ig G antibodies.

Results: Among the samples 18/232 (7.75%) were found IgM positive and 25/232 (10.77%) were found IgG positive. Similarly, 12/232 (5.17%) showed both IgG and IgM positive; however, all sample tested negative for NS1 Conclusions: Detection of Dengue antibodies in asymptomatic blood donors in endemic areas indicates a potential risk for recipients to contract dengue infection through blood transfusion. Implementing a screening program during dengue outbreaks could effectively mitigate this risk.

本刊更多论文

血库健康献血者登革热血清阳性率分析。

背景：登革热是一种病毒性感染，常见于全球热带和亚热带地区，特别是城市和半城市地区。在过去二十年中，登革热病例显著增加。本研究旨在确定尼泊尔医学院血库健康献血者中登革热NS1抗原、IgM和IgG抗体的流行情况。方法：于2023年8月至11月在尼泊尔医学院血库进行描述性横断面研究。获得了尼泊尔医学院机构审查委员会（Ref: -080/081）的伦理批准。采用登革双联（SD Bioline Dengue Duo）对32份健康献血者血清进行NS1抗原、IgM和Ig G抗体的检测。结果：IgM阳性18/232 (7.75%)，IgG阳性25/232（10.77%）。同样，12/232 (5.17%)IgG和IgM均阳性；结论：在流行地区无症状献血者中检测到登革热抗体表明，接受者存在通过输血感染登革热的潜在风险。在登革热暴发期间实施筛查规划可有效减轻这一风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nepal Health Research Council Medicine-Medicine (all)

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： The journal publishes articles related to researches done in the field of biomedical sciences related to all the discipline of the medical sciences, medical education, public health, health care management, including ethical and social issues pertaining to health. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews and meta-analysis. Editorial, Guest Editorial, Viewpoint and letter to the editor are solicited by the editorial board. Frequently Asked Questions (FAQ) regarding manuscript submission and processing at JNHRC.