Association of cataract surgery with stroke among older adults in the United States.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI:10.1038/s41433-025-03662-z

Tsung-Hsien Tsai, Yuan-Ting Chang, Yu-Chen Cheng

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引用次数: 0

Abstract

Background/objectives: Cataract surgery, one of the most frequent conducted surgeries around the world, is associated with cardiovascular diseases. We aim to determine the association of cataract surgery and the risk of stroke.

Methods: Adults aged over 65 years old in the National Health and Aging Trends Study were followed 7 years annually. There were 6700 stroke-free participants included at baseline survey. These participants were divided into two groups based on past history of cataract surgery. Demographics and multiple comorbidities were compared between the two groups. We identified newly developed cases of stroke over a 7-year period and performed survival analysis. Cox regression was further performed to yield adjusted hazard ratios.

Results: Among 6700 elderly participants, 2803 of them had a history of cataract surgery while 3897 of them had not. Over the 7-year follow-up period, the cumulative stroke-free survival rate among the cataract surgery group and the control group were 84.4% versus 88.6% (p < 0.0001, log-rank test). Compared with the control group, elderly with a history of cataract surgery had a higher risk of developing stroke (adjusted HR 1.36, 95% CI 1.03 to 1.79, p = 0.026) after adjusting for multiple covariates. Other significant predictors included age ≥80 years old, having comorbidities with heart disease, lung disease, and dementia. Contrarily, protective factors for further stroke development included higher education and more frequent outdoor activities.

Conclusions: Our findings suggest that patients with a history of cataract surgery had a 1.36-fold increased risk of future stroke development.

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美国老年人白内障手术与中风的关系。

背景/目的：白内障手术是世界上最常见的手术之一，与心血管疾病有关。我们的目的是确定白内障手术与中风风险的关系。方法：对参加国家健康与老龄化趋势研究的65岁以上老年人进行每年7年的随访。基线调查包括6700名无中风的参与者。这些参与者根据过去的白内障手术史分为两组。比较两组患者的人口统计学特征和多种合并症。我们确定了在7年的时间里新发生的中风病例，并进行了生存分析。进一步进行Cox回归得到调整后的风险比。结果：6700名老年人中，2803人有白内障手术史，3897人没有白内障手术史。在7年的随访期间，白内障手术组和对照组的累计无卒中生存率分别为84.4%和88.6% (p)。结论：我们的研究结果表明，有白内障手术史的患者未来发生卒中的风险增加了1.36倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.