Inflammatory cytokine levels in rheumatic heart disease and their association with use of benzathine penicillin: A case-control pilot study

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian heart journal Pub Date : 2025-03-01 DOI:10.1016/j.ihj.2025.01.007

Sanjeev Kumar , Prakash Chand Negi , Sanjeev Asotra , Meenakshi Chandel , Jitender Kumar , Rajeev Merwah , Rajesh Sharma , Ritesh Kumar , Vinay Bhardwaj , Preetam Singh Thakur

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引用次数: 0

Abstract

Background

Valvular inflammation plays an important role in the progression of Rheumatic Heart Disease. We report the association between inflammatory markers and use of Benzathine Penicillin G in patients with Rheumatic mitral valve disease.

Methods

The levels of inflammatory cytokines; IL-1β, IL-6, TNF-α and inflammatory marker hs- CRP were measured using ELISA method in 32 patients with RHD receiving Benzathine Penicillin as secondary prophylaxis and 31 patients not receiving secondary prophylaxis, in a case–control study. The severity and type of valvular dysfunction were assessed with echocardiogram.

Results

The median level of IL-1β was significantly lower in patients on BPG (0.95 pg/ml vs. 5.47 pg/ml) p < 0.002. The median levels of IL-6, TNF-α and hs-CRP were not significantly different between study groups. The adjusted odds of raised IL-1β were lower in patients on BPG (odds ratio 0.40, 95 % C.I. 0.11, 1.45) p 0.16. There was a trend of inverse association between the use of BPG and mitral stenosis (odds ratio 0.42, 95 % C.I. (0.12, 1.46) p 0.17.

Conclusion

Patients with RHD on BPG had lower levels of IL-1β and a trend toward a lower prevalence of mitral stenosis. Role of IL-1β in progression of incompetent to stenotic mitral valve dysfunction needs to be explored in future studies.

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风湿性心脏病的炎症细胞因子水平及其与苄星青霉素使用的关系：一项病例对照初步研究

背景：瓣膜炎症在风湿性心脏病的进展中起重要作用。我们报道炎症标志物与风湿性二尖瓣疾病患者使用苄星青霉素G之间的关系。方法：炎性细胞因子水平；采用ELISA法对32例接受苄星青霉素二级预防治疗的RHD患者和31例未接受二级预防治疗的RHD患者进行IL-1β、IL-6、TNF-α和炎症标志物hs- CRP的检测。用超声心动图评估瓣膜功能障碍的严重程度和类型。结果：BPG组患者IL-1β中位水平显著降低（0.95 pg/ml vs. 5.47 pg/ml）。结论：BPG组RHD患者IL-1β水平较低，二尖瓣狭窄发生率较低。IL-1β在功能不全到狭窄型二尖瓣功能障碍进展中的作用有待进一步研究。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.