GNOme, an ontology for glycan naming and subsumption.

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Analytical and Bioanalytical Chemistry Pub Date : 2025-02-08 DOI:10.1007/s00216-025-05757-8

Wenjin Zhang, Michelle Vesser, Nathan Edwards

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引用次数: 0

Abstract

While GlyTouCan provides stable identifiers for referencing glycan structures, they are not organized semantically. GNOme, a glycan naming and subsumption ontology and a member of the OBOFoundry, organizes GlyTouCan accessions for automated reasoning and interactive browsing of glycan structures by subsumption. GNOme makes it quick and easy to discover glycans with a specific degree of characterization; provides a text-based table of common synonyms for specific structures and compositions; enumerates glycan subsumption relationships for automated reasoning; and assigns each glycan to well-defined categories based on their degree of characterization. As an OBOFoundry ontology, GNOme can be readily integrated with other OBOFoundry ontologies and standards initiatives that need to refer to glycans with various degrees of characterization. GNOme is integrated with GlyGen, a glycoinformatics knowledge base, providing navigation to "related glycans," and expanding the utility of species and glycan classification annotations. GNOme is available at https://gnome.glyomics.org/ and via GlyGen, the OBO Foundry, and GitHub.

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.